Product Literature - Virus Packaging_Adeno-associated virus (AAV)_Adenovirus_Neurotransmitter(NT) Fluorescent Sensors_jGCaMP7_AAV Serotype Screening_Lentivirus_LV_ADV_|AAV_Retrovirus_Optogenetics_Chemical Genetics_CRISPR/Cas9_Autophagy(LC3)_Stable Cell Line Generation

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Plasmid

ORF Ready-to-Use Plasmids
● Autophagy. (IF=13.391). Ruolin Li, et.al. (2021). Piperine promotes autophagy flux by P2RX4 activation in SNCA/α-synuclein-induced Parkinson disease model. [Capital Medical University, SNCA overexpression plasmid, autophagy, Parkinson's disease]
● NATURE COMMUNICATIONS. (IF=17.694). Xiaolong Tang, et.al. (2021). Combined intermittent fasting and ERK inhibition enhance the anti-tumor effects of chemotherapy via the GSK3β-SIRT7 axis. [Zhejiang University, FLAG-AMPKα1 & FLAG-SKP2 & FLAG-AKT1 overexpression plasmids, malignant tumor]
● NATURE COMMUNICATIONS. (IF=17.694). Lijuan Zhang, et.al. (2021). Loss of fragile site-associated tumor suppressor promotes antitumor immunity via macrophage Polarization. [Tianjin Medical University, Myc-IkBa & HA-UB K48, macrophage]
● J Immunother Cancer. (IF=12.469). Rui Qin, et.al. (2021). Tryptophan potentiates CD8+ T cells against cancer cells by TRIP12 tryptophanylation and surface PD-1 downregulation. [Fudan University, NFATc overexpression plasmid, tryptophan-mediated immune activation]
● Genome Biology. (IF=17.906). Xujia Wu, et.al. (2021). A novel protein encoded by circular SMO RNA is essential for Hedgehog signaling activation and glioblastoma tumorigenicity. [The First Affiliated Hospital of Sun Yat-sen University, PTCH1 & Gli1 overexpression plasmids, glioblastoma]
● Neuro-Oncology. (IF=13.029). Kaikai Yi, et.al. (2021). PTRF/cavin-1 remodels phospholipid metabolism to promote tumor proliferation and suppress immune responses in glioblastoma by stabilizing cPLA2. [Tianjin Medical University, PTRF overexpression plasmid, glioblastoma]
● EMBO Molecular Medicine. (IF=14.260). Xujia Wu, et.al. (2021). Nanog maintains stemness of Lkb1-deficient lung adenocarcinoma and prevents gastric differentiation. [Chinese Academy of Sciences, NANOG overexpression plasmid, lung cancer]
● Cell Death & Disease. (IF=6.304). Hao et al. (2020). Dual regulation of p53 by the ribosome maturation factor SBDS. [Fudan University, SBDS overexpression plasmid, lung cancer and colon cancer]
● Cell Death & Disease. (IF=6.304). Fu et al. (2020). Activation of STAT3 is a key event in TLR4 signaling-mediated melanoma progression. [Hong Kong Baptist University, TLR4 overexpression plasmid, melanoma]
● Biochemical Pharmacology. (IF=4.96). Li et al. (2020). Downregulation of OCTN2 by Cytokines Plays an Important Role in the Progression of Inflammatory Bowel Disease. [Zhejiang University, SLC22A5 overexpression plasmid, HT29&FHC cells, inflammatory bowel disease (IBD)]
● Cancer Letters. (IF=7.36). Liu et al. (2020). MICAL2 is a novel nucleocytoplasmic shuttling protein promoting cancer invasion and growth of lung adenocarcinoma. [Xiangya Hospital of Central South University, MYH9 overexpression plasmid, lung cancer cells]
● Cancer Letters. (IF=7.36). Luo et al. (2019). DMBX1 promotes tumor proliferation and regulates cell cycle progression via repressing OTX2-mediated transcription of p21 in lung adenocarcinoma cell. [Jiangsu Cancer Hospital, lung cancer cells]
● Redox Biology. (IF=9.986). Tian et al. (2019). aPKCι promotes gallbladder cancer tumorigenesis and gemcitabine resistance by competing with Nrf2 for binding to Keap1. [Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, PRKCI & KEAP1 expression plasmids, gallbladder cancer]

microRNA Ready-to-Use Plasmids
● Phytomedicine. (IF 7.9). Pan et.al. (2023). Synergistic neuroprotective effects of two natural medicinal plants against CORT-induced nerve cell injury by correcting neurotransmitter deficits and inflammation imbalance. [School of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, miRNA-144-3p overexpression and knockdown plasmids, nerve]
● Pharmacological Research. (IF=5.893). Huang et al. (2020). MiR-377-3p suppresses colorectal cancer through negative regulation on Wnt/β-catenin signaling by targeting XIAP and ZEB2. [Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, miR-377 overexpression plasmid, colorectal cancer]
● PPAR Research. (IF=2.953). Xu et al. (2019). Peroxisome Proliferator-Activated Receptor-γ Antagonizes LOX-1-Mediated Endothelial Injury by Transcriptional Activation of miR-590-5p. [Zhongshan Hospital, Fudan University, miR-590 overexpression plasmid, endothelial injury]
● Theranostics. (IF=8.579). Song et al. (2019). Localized injection of miRNA-21-enriched extracellular vesicles effectively restores cardiac function after myocardial infarction. [Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, miR-21 overexpression plasmid, acute myocardial infarction (MI)]

Custom Plasmids
● Experimental Hematology & Oncology (IF=9.4). Huang S, et.al. (2024). Combined inhibition of MET and VEGF enhances therapeutic efficacy of EGFR TKIs in EGFR-mutant non-small cell lung cancer with concomitant aberrant MET activation. [Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, luciferase reporter plasmid construction service, EGFR-mutant non-small cell lung cancer]
● Annals of the Rheumatic Diseases. (IF 27.4). Zhao et.al. (2023). SGLT2 inhibitors alleviated podocyte damage in lupus nephritis by decreasing inflammation and enhancing autophagy. [The First Affiliated Hospital of Zhengzhou University, sgRNA plasmid]
● J Immunother Cancer. (IF=12.469). Qi-Hua Peng, et.al. (2021). CMTM6 and PD-L1 coexpression is associated with an active immune microenvironment and a favorable prognosis in colorectal cancer. [Sun Yat-sen University, pEnter-CMTM6-Flag overexpression plasmid, colorectal cancer]
● Cell Death Dis. (IF=6.304). Ma, et al. (2020). circ5615 functions as a ceRNA to promote colorectal cancer progression by upregulating TNKS. [Jiangsu Cancer Hospital, pAV-circRNA 5615, colorectal cancer]
● Toxicol. Appl. Pharmacol. (IF=3.347). Ge & Tu, et al. (2020). MiR-122-5p increases radiosensitivity and aggravates radiation-induced rectal injury through CCAR1. [Shanghai General Hospital & Shanghai Jiao Tong University School of Medicine, pcDNA3.1-FLAG-CCAR1, radiation-induced rectal injury]
● Cell Death Dis. (IF=6.304). Zhang, et al. (2019). circHIPK3 regulates lung fibroblast-to-myofibroblast transition by functioning as a competing endogenous RNA. [Shanghai Jiao Tong University School of Medicine, pADM-circHIPK3-GFP, pulmonary fibrosis]
● Int J Med Sci. (IF=2.523). Wang, et al. (2019). LncRNA SNHG6 promotes proliferation, invasion and migration in colorectal cancer cells by activating TGF-β/Smad signaling pathway via targeting UPF1 and inducing EMT via regulation of ZEB1. [Southern Medical University, pCMV-SNHG6, colorectal cancer]
● EBioMedicine. (IF=5.736). Jiang, et al. (2019). Overexpression of PIMREG promotes breast cancer aggressiveness via constitutive activation of NF-κB signaling. [Guangzhou Medical University, HA-tagged full-length p65 and the truncated p65 fragments plasmids, breast cancer]
● Aging (Albany NY). (IF=4.831). Li, et al. (2019). Sirt1-inducible deacetylation of p21 promotes cardiomyocyte proliferation. [Nanfang Hospital, Southern Medical University, pcDNA3.1-FLAG-p21 WT & pcDNA3.1-FLAG-p21 KR & pcDNA3.1-FLAG-p21 KQ, cardiomyocyte proliferation]
● R Soc Open Sci. (IF=2.647). Liu, et al. (2018). Loss of miR-143 and miR-145 in condyloma acuminatum promotes cellular proliferation and inhibits apoptosis by targeting NRAS. [The First Affiliated Hospital of Zhejiang University School of Medicine, pSH-U6-miR-143-5p-gRNA(or miR-143-3p-gRNA/miR-145-5p-gRNA/miR-145-3p-gRNA)-CMV-SpCas9-P2A-Puro, human epidermal keratinocytes (HEKs), condyloma acuminatum (CA)]
Adenovirus

ORF Ready-to-Use Adenoviruses
● International Journal of Oral Science（IF 14.9）. Zhang DX.（2024）. Phenformin activates ER stress to promote autophagic cell death via NIBAN1 and DDIT4 in oral squamous cell carcinoma independent of AMPK. [Shandong University, AdV5-CMV-GFP-LC3, AdV5-GFP-RFP-LC3, CAL 27 cells (human tongue squamous cell carcinoma), MOI 100, oral squamous cell carcinoma.]
● Biol Psychiatry. (IF=12.095). Zhao D, et al. (2019). RPS23RG1 Is Required for Synaptic Integrity and Rescues Alzheimer's Disease-Associated Cognitive Deficits. [Xiamen University, Ad-PSD-95 & Ad-control GFP, Alzheimer's disease]
● J Clin Endocrinol Metab. (IF=5.399). Li M, et al. (2019). The HMGA2-IMP2 Pathway Promotes Granulosa Cell Proliferation in Polycystic Ovary Syndrome. [Shandong University, Ad-HMGA2, polycystic ovary syndrome]
● Int J Cardiol. (IF=3.229). Wu B, et al. (2018). Mesoderm/mesenchyme homeobox gene l promotes vascular smooth muscle cell phenotypic modulation and vascular remodeling. [Hubei University of Medicine, Ad-Meox1, vascular remodeling]
● Life Sci. (IF=6.304). He M, et al. (2018). In vitro study of FUZ as a novel potential therapeutic target in non-small-cell lung cancer. [Peking University, Ad-FUZ & Ad-NC, non-small cell lung cancer]
● Cell Death Dis. (IF=6.304). Sun S, et al. (2017). Loss of the novel mitochondrial protein FAM210B promotes metastasis via PDK4-dependent metabolic reprogramming. [Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Ad-PDK4, cancer metabolism]
● Molecular Medicine Reports. (IF=2.1). Zhang S, et al. (2017). PAR1-mediated c-Jun activation promotes heat stress-induced early stage apoptosis of human umbilical vein endothelial cells. [Nanfang Hospital, Southern Medical University, Ad-PAR1, heat stress-induced apoptosis in HUVECs]
● Hepatology. (IF=14.679). Xiang D, et al. (2017). Shp2 promotes liver cancer stem cell expansion by augmenting β-catenin signaling and predicts chemotherapeutic response of patients. [Eastern Hepatobiliary Surgery Hospital, AdShp2 and AdGFP, liver cancer]
● Cancer Letters. (IF=7.36). Wang Z, et al. (2017). CXCL1 from tumor-associated lymphatic endothelial cells drives gastric cancer cell into lymphatic system via activating integrinβ1/FAK/AKT signaling. [The First Affiliated Hospital of Sun Yat-sen University, Ad-CXCL1, gastric cancer]
● Gene. (IF=2.984). Zhang J W, et al. (2017). Validation of aspirin response-related transcripts in patients with coronary artery disease and preliminary investigation on CMTM5 function. [Peking University First Hospital, Ad-CMTM5-v1 & Ad-mock, coronary artery disease]
● Cell Death Dis. (IF=6.304). Zheng Y, et al. (2017). Berbamine postconditioning protects the heart from ischemia/reperfusion injury through modulation of autophagy. [Shanghai Jiao Tong University School of Medicine & Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Ad-Atg5, ischemic heart disease]
● Oncoimmunology. (IF=5.869). Wang H, et al. (2016). Interactions between colon cancer cells and tumor-infiltrated macrophages depend on cancer cell-derived colony stimulating factor 1. [Qilu Hospital of Shandong University, Ad-hCSF1 intratumoral injection, colon cancer]
● Basic Res Cardiol. (IF=11.981). Sun Z, et al. (2016). Cross-talk between macrophages and atrial myocytes in atrial fibrillation. [The First Affiliated Hospital of Zhejiang University School of Medicine, Ad-QKI, atrial fibrillation]
● Mol Carcinog. (IF=3.825). Wang J, et al. (2016). Endothelial cell-anchored tissue factor pathway inhibitor regulates tumor metastasis to the lung in mice. [Fudan University, Ad-TFPI & Ad-GFP, tumor]

MicroRNA Ready-to-Use Adenoviruses
● Frontiers in Immunology. (IF 8.786). Huang et.al. (2023). FGL2 deficiency alleviates maternal inflammation-induced blood-brain barrier damage by blocking PI3K/NF-κB mediated endothelial oxidative stress. [Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Ad-FGL2-miRNA, blood-brain barrier]
● Hypertension. (IF=9.897). Junni Wang，et.al.（2021）. MicroRNA-874-3p/ADAM (A Disintegrin and Metalloprotease) 19 Mediates Macrophage Activation and Renal Fibrosis After Acute Kidney Injury. [The First Affiliated Hospital of Zhejiang University, Ad-miR-874-3p, renal fibrosis]
● Stem Cells Int. (IF=3.869). Li X, et al. (2019). MicroRNA-150 Modulates Adipogenic Differentiation of Adipose-Derived Stem Cells by Targeting Notch3. [China Medical University, Ad-miR-150, adipose-derived stem cells]
● Oncotarget. (IF=5.168). Tian S, et al. (2017). miR-138-5p suppresses autophagy in pancreatic cancer by targeting SIRT1. [The Affiliated Hospital of Guizhou Medical University, Ad-miR-138-5p & Ad-miR-NC, autophagy in pancreatic cancer cells]

Gene Overexpression
● Cell Communication and Signaling (IF=8.2). Ren X, et.al. (2025). REG3A secreted by peritumoral acinar cells enhances pancreatic ductal adenocarcinoma progression via activation of EGFR signaling. [Nanjing Medical University, Ad-Vec, Ad-REG3A, Ad-ΔREG3A, pancreatic ductal adenocarcinoma]
● Journal of Hazardous Materials (IF=12.2). Zhang Y, et.al. (2025). F-53B disrupts energy metabolism by inhibiting the V-ATPase-AMPK axis in neuronal cells. [School of Medicine, Shihezi University, Ad-V-ATPase B2, neurotoxicity]
● Journal of Advanced Research（IF=11.4）. Sun K, et.al. (2024). TRPM2-mediated feed-forward loop promotes chondrocyte damage in osteoarthritis via calcium-cGAS-STING-NF-κB pathway. [Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology & Wuhan Fourth Hospital, Ad-TRPM2, Ad-GFP, osteoarthritis]
● Cancer Immunology Research (IF 8.1). Xiang X, et.al. (2024). Blocking CX3CR1+ Tumor-associated Macrophages Enhances the Efficacy of Anti-PD-1 Therapy in Hepatocellular Carcinoma. [Hangzhou Medical College, Ad-CX3CR1, Ad-NC, hepatocellular carcinoma]
● Signal Transduction and Targeted Therapy (IF 40.8). Fang L, et.al. (2024). Annexin A1 binds PDZ and LIM domain 7 to inhibit adipogenesis and prevent obesity. [Peking University / South China University of Technology / Southwest Medical University, Ad-SMAD4, Ad-MYCBP2, Ad-NC, obesity]
● Cell Death & Disease (IF 8.1). Peng et.al. (2024). Tripartite motif 8 promotes the progression of hepatocellular carcinoma via mediating ubiquitination of HNF1α. [Team of Xie Weifen and Zhang Xin, Shanghai Changzheng Hospital, Ad-HNF1α(K197R), liver cancer]
● Cell & Bioscience（IF 7.9）. Lei ZY.（2024）. Med1 inhibits ferroptosis and alleviates liver injury in acute liver failure via Nrf2 activation. [The Third Affiliated Hospital of Sun Yat-sen University, Ad-CMV-Med1, tail vein injection, 3.6×10⁹ PFU, acute liver failure]
● Cell Communication and Signaling ( IF 8.2 ). Ma et.al. (2024). Low concentrations of saracatinib promote definitive endoderm differentiation through inhibition of FAK-YAP signaling axis. [Team of Ding Xiaoming, The First Affiliated Hospital of Xi'an Jiao Tong University, definitive endoderm differentiation]
● Redox Biology (IF 11.4). Shao et.al. (2024). FOXO1 regulates RUNX2 ubiquitination through SMURF2 in calcific aortic valve disease. [Team of Dong Nianguo and Li Fei, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, in collaboration with The First Affiliated Hospital of Nanjing Medical University, calcific aortic valve disease]
● Molecular Metabolism (IF 8.1). Li J, et.al. (2024). Tyrosine-phosphorylated DNER sensitizes insulin signaling in hepatic gluconeogenesis by inducing proteasomal degradation of TRB3. [Renmin Hospital of Wuhan University, Ad-DNER, Ad-DNER (Tyr677 to Ala), Ad-HA, hepatic gluconeogenesis]
● Journal of Nanobiotechnology (IF 10.2). Ye L, et.al. (2024). Modulation of alveolar macrophage and mitochondrial fitness by medicinal plant-derived nanovesicles to mitigate acute lung injury and viral pneumonia. [Institute of Translational Medicine, Zhejiang Shuren University, Ad-ACE2, acute lung injury and viral pneumonia]
● Nature Communications（IF 16.6）. Wang SJ.（2024）. Sequential glycosylations at the multibasic cleavage site of SARS-CoV-2 spike protein regulate viral activity. [Sun Yat-sen University, The First Affiliated Hospital of Guangzhou Medical University, Ad5-GALNT3/T7, Ad5-EV, human lung adenocarcinoma Calu-3 cells, MOI 1000, SARS-CoV-2 defense mechanism]
● VIEW（IF 8.6）. Zhu JW.（2023）. The PES1/FOXM1 heterodimer suppresses TCF21 and ERβ expression in ovarian endometriosis. [Peking University First Hospital, Ad-Pes1, Ad-vector, in vivo injection 10⁹ pfu, endometriosis]
● Acta Pharmaceutica Sinica B (IF 14.5). Rong et.al. (2024). Inhibition of xanthine oxidase alleviated pancreatic necrosis via HIF1α-regulated LDHA and NLRP3 signaling pathway in acute pancreatitis. [Team of Du Dan and Xia Qing, West China Hospital, Ad-XDH, pancreatitis]
● Cell Metabolism（IF 29）. Dong YM.（2024）. A clinical-stage Nrf2 activator suppresses osteoclast differentiation via the iron-ornithine axis. [Tongji Hospital, Huazhong University of Science and Technology, Ad-shRNA-Slc40a1 (pAd-4 in 1 shRNA), bone marrow-derived macrophages, MOI 200, osteoporosis]
● Advanced Science（IF 15.1）. Ding L.（2024）. Beta-Cell Tipe1 Orchestrates Insulin Secretion and Cell Proliferation by Promoting Gαs/cAMP Signaling via USP5. [School of Basic Medical Sciences, Shandong University, Ad-CMV-Gnas, Ad-CMV-Tipe1, MIN6 cells / Islets cells, type 2 diabetes]
● Journal of Medical Virology (IF 12.7). Yu et.al. (2023). SARS-CoV-2 nucleocapsid protein enhances the level of mitochondrial reactive oxygen species. [School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Ad5-S2NP]
● BMC Biology（IF 5.4）. You WJ.（2023）. GADD45A regulates subcutaneous fat deposition and lipid metabolism by interacting with Stat1. [Zhejiang University, Ad-Gadd45a, Ad-Ctrl, mouse / porcine subcutaneous adipocytes, lipid metabolism]
● J Clin Invest，（IF 15.9）. Yang ZY.（2023）. Repression of rRNA gene transcription by endothelial SPEN deficiency normalizes tumor vasculature via nucleolar stress. [The Fourth Military Medical University, Ad-CTCF, Ad-Ctrl, human umbilical vein endothelial cells (HUVECs), MOI 200, tumor blood vessels]
● Metabolism，（IF 9.8）. Hu YT.（2023）. Hepatocyte-secreted FAM3D ameliorates hepatic steatosis by activating FPR1-hnRNP U-GR-SCAD pathway to enhance lipid oxidation. [School of Basic Medical Sciences, Peking University Health Science Center, Peking University People's Hospital, AAV8-FPR1, AAV8-GFP, tail vein injection, hepatic lipid metabolism]
● Acta Pharmacologica Sinica（IF8.2）. Huang YM, et.al. (2023). Par3L, a polarity protein, promotes M1 macrophage polarization and aggravates atherosclerosis in mice via p65 and ERK activation. [Guangzhou Medical University, Ad-hPar3L, Ad-GFP, atherosclerotic cardiovascular disease]
● Journal of Translational Medicine (IF=7.4). Xiong W, et.al. (2023). UCP1 alleviates renal interstitial fibrosis progression through oxidative stress pathway mediated by SIRT3 protein stability. [Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Ad-UCP1, Ad-Ctrl, renal interstitial fibrosis]
● Free Radical Biology and Medicine. (IF 7.4). Zhang et.al. (2023). Frataxin inhibits the sensitivity of the myocardium to ferroptosis by regulating iron homeostasis. [School of Basic Medicine, The Fourth Military Medical University, Xijing Hospital of The Fourth Military Medical University, AAV and adenovirus overexpression vector AAV9-cTNT-frataxin, Ad-Frataxin, heart]
● JACC-Basic to Translational Science，（IF 9.531）. Zhu ZY.（2023）. Deficiency of GDF-11 Accelerates TAC-Induced Heart Failure by Impairing Cardiac Angiogenesis. [The Second Affiliated Hospital of Zhejiang University School of Medicine, Adv-shGDF-11, cardiomyocytes (CMs), MOI=200, heart failure]
● Journal of Molecular Medicine，（IF 5.606）. Shao SY.（2023）. Never in mitosis gene A-related kinase-6 deficiency deteriorates diabetic cardiomyopathy via regulating heat shock protein 72. [The First Affiliated Hospital of Zhengzhou University, Ad-NEK6, MOI=50, cardiomyocytes, diabetic cardiomyopathy]
● Signal Transduction and Targeted Therapy（IF 39.3）. Chunsik Lee. et.al.（2023）. VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway. [Zhongshan Ophthalmic Center, Sun Yat-sen University, Karolinska Institutet (Sweden) in collaboration with Eye & ENT Hospital of Fudan University, Ad-FGFR1 WT, Ad-FGFR1 Y463F, Ad-FGFR1 Y585F, Ad-FGFR1 Y653F, human umbilical vein endothelial cells-HUVECs, MOI=10, blood vessels]
● iScience （IF 6.107）. Li YJ.（2023）. Phosphodiesterase type 10A inhibitor attenuates lung fibrosis by targeting myofibroblast activation. [Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, pADM-PDE10A, human embryonic lung fibroblasts (HFL-1), pulmonary fibrosis]
● ISCIENCE. (IF 6.107). Guo et.al. (2023). Steroidogenic factor 1 protects mice from obesity-induced glucose intolerance via improving glucose-stimulated insulin secretion by beta cells. [The First Affiliated Hospital of Sun Yat-sen University, AAV and adenovirus overexpression vector, pancreas]
● Journal of Translational Medicine. (IF=8.44). Zhang RN, et.al. (2023). The spatiotemporal matching pattern of Ezrin/Periaxin involved in myoblast differentiation and fusion and Charcot-Marie-Tooth disease-associated muscle atrophy. [Hubei University of Medicine, Ad-NFATc1, Ad-NFATc2, Ad-shNFATc3, Ad-shNFATc4, Ad-Null, Charcot-Marie-Tooth disease]
● J CELL COMMUN SIGNAL.（IF=5.908）. Liu X, et.al. (2023). Sam68 promotes osteogenic differentiation of aortic valvular interstitial cells by TNF‑α/STAT3/autophagy axis. [Wuhan Union Hospital, Ad-Sam68, calcific aortic valve disease]
● Journal of Nutritional Biochemistry.（IF=6.117）. Liu J, et.al. (2023). Iron-frataxin involved in the protective effect of quercetin against alcohol-induced liver mitochondrial dysfunction. [School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Ad-Frataxin, alcoholic liver disease]
● Acta Pharmacologica Sinica. (IF 7.169). Guo et.al. (2023). JMJD6 protects against isoproterenol-induced cardiac hypertrophy via inhibition of NF-κB activation by demethylating R149 of the p65 subunit. [Shandong First Medical University, JMJD6 adenovirus overexpression vector, cardiac hypertrophy]
● Journal of Neuroinflammation. (IF 9.587). Qian Xia et.al. (2022). Sirtuin 5 aggravates microglia-induced neuroinflammation following ischaemic stroke by modulating the desuccinylation of Annexin-A1. [Tongji Hospital, Huazhong University of Science and Technology, SIRT5 adenovirus overexpression and knockdown vector, neuroinflammation]
● Ecotoxicology and Environmental Safety. (IF 7.129). Jingjing Zhang et.al. (2023). The inhibition of TRPML1 TFEB leads to lysosomal biogenesis disorder contributes to developmental fluoride neurotoxicity. [Xinjiang Shihezi University, TFEB adenovirus overexpression vector, fluoride neurotoxicity]
● ARTERIOSCL THROM VAS（IF=10.514）. Shu Liu，et.al.（2022）. Long Noncoding RNA TPRG1-AS1 Suppresses Migration of Vascular Smooth Muscle Cells and Attenuates Atherogenesis via Interacting With MYH9 Protein. [Fuwai Hospital, Chinese Academy of Medical Sciences, AdV-TPRG1-AS1 and AdV-MYH9, atherosclerosis]
● Journal of Cachexia, Sarcopenia and Muscle.（IF=12.063）. You W, et.al. (2022). Growth arrest and DNA damage-inducible alpha regulates muscle repair and fat infiltration through ATP synthase F1 subunit alpha. [College of Animal Sciences, Zhejiang University, Ad-GADD45A, intramuscular fat deposition]
● Free Radical Biology and Medicine. (IF 8.101). Liu Y, et.al. (2022). LRRK2 deficiency protects the heart against myocardial infarction injury in mice via the P53/HMGB1 pathway. [The First Affiliated Hospital of Zhengzhou University, Ad-LRRK2 & Ad-LRRK2 D1994A & Ad-NC, myocardial infarction]
● Journal of Molecular and Cellular Cardiology.（IF=5.763）. Wang S, et.al. (2022). Deletion of SIRT6 in vascular smooth muscle cells facilitates vascular calcification via suppression of DNA damage repair. [Zhongshan School of Medicine, Sun Yat-sen University & Zhujiang Hospital, Southern Medical University, Ad-SIRT6 & Ad-GFP, vascular calcification]
● Molecular Neurobiology. (IF=5.682). Zhou B, et.al. (2022). FUS Mutation Causes Disordered Lipid Metabolism in Skeletal Muscle Associated with ALS. [The First Affiliated Hospital of Nanchang University, Ad-FUS & Ad-FUS-K510Q, amyotrophic lateral sclerosis]
● Cell and Bioscience. (IF=9.584). Mao M, et.al. (2022). SENP6 induces microglial polarization and neuroinflammation through de-SUMOylation of Annexin-A1 after cerebral ischaemia–reperfusion injury. [Tongji Hospital, Huazhong University of Science and Technology & Central Hospital Affiliated to Zhengzhou University, Ad-SENP6 & Ad-vector, stroke]
● Arterioscler Thromb Vasc Biol.（IF=10.514）. Ren X, et.al. (2022). Long Noncoding RNA TPRG1-AS1 Suppresses Migration of Vascular Smooth Muscle Cells and Attenuates Atherogenesis via Interacting With MYH9 Protein. [Fuwai Hospital, Chinese Academy of Medical Sciences, Ad-TPRG1-AS1 & Ad-MYH9, atherosclerotic cardiovascular disease]
● Pharmacol Res.(IF=10.334). Zhu S, et al. (2022). The miR-145-MMP1 axis is a critical regulator for imiquimod-induced cancer stemness and chemoresistance. [Translational Medicine Institute, The First Hospital of Jilin University, Ad-miR-145 & Ad-control, cancer stemness]
● Acta Biomaterialia.（IF=10.633）. Wang F, et.al. (2022). Adipose-derived stem cells with miR-150-5p inhibition laden in hydroxyapatite/tricalcium phosphate ceramic powders promote osteogenesis via regulating Notch3 and activating FAK/ERK and RhoA. [China Medical University, Ad-miR-150-5p & Ad-NC, osteoporosis]
● Molecular Cancer. (IF=41.444). Lei Liu，et.al.（2021）. KDM6A-ARHGDIB axis blocks metastasis of bladder cancer by inhibiting Rac1. [Shandong University, Ad-KDM6A & Ad-GFP, bladder cancer]
● Signal Transduction and Targeted Therapy.（IF=38.104）. Suowen Xu, et.al.（2021）. The zinc finger transcription factor, KLF2, protects against COVID-19 associated endothelial dysfunction. [University of Science and Technology of China, Ad-KLF2 & Ad-GFP, endothelial dysfunction]
● Redox Biology .(IF=10.787). Yaqian Huang，et.al.（2021）. Endogenous SO2-dependent Smad3 redox modification controls vascular remodeling. [Peking University First Hospital, Ad-AAT1, vascular remodeling]
● Theranostics.（IF=38.104）. Yan Jiang, et.al.（2021）. Histone H3K27 methyltransferase EZH2 and demethylase JMJD3 regulate hepatic stellate cells activation and liver fibrosis. [Fudan University, Ad-Jmjd3 & Ad-Jmjd3-mut, liver fibrosis]
● Nat Commun. (IF=17.694). Liu R, et.al. (2022). MicroRNA-21 promotes pancreatic β cell function through modulating glucose uptake. [Shandong First Medical University Affiliated Eye Institute, Ad-GFP＆Ad-CMV-Glut2＆Ad-insulin 1-miR-21, pancreatic β cells]
● Cell Metab. (IF=27.287). Zhou N, et.al. (2022). Deubiquitinase OTUD3 regulates metabolism homeostasis in response to nutritional stresses. [Peking University & Shandong First Medical University Affiliated Provincial Hospital, Ad-PPARd & Ad-OTUD3&Ad-control, glucose and lipid metabolism]
● Genes & Diseases. (IF=7.103). Luo J, et.al. (2022). PLSCR1 Promotes Apoptosis and Clearance of Retinal Ganglion Cells in Glaucoma Pathogenesis. [Sun Yat-sen University, Ad-PLSCR1&Ad-control, glaucoma]
● J Cell Physiol. (IF=5.546). Wang M, et al. (2021). Lack of Mof reduces acute liver injury by enhancing transcriptional activation of Igf1. [Overexpression/Knockdown, acute liver injury]
● Front Cell Dev Biol. (IF=5.201). Gu J, et al. (2021). CFTR Deficiency Affects Glucose Homeostasis via Regulating GLUT4 Plasma Membrane Transportation. [Overexpression, myoblasts]
● Front Immunol. (IF=5.085). Wu L, et al. (2021). EZH2 Inhibition Interferes With the Activation of Type I Interferon Signaling Pathway and Ameliorates Lupus Nephritis in NZB/NZW F1 Mice. [Overexpression, lupus nephritis]
● Oxid Med Cell Longev. (IF=5.076). Gao Y, et al. (2021). Rap1GAP Mediates Angiotensin II-Induced Cardiomyocyte Hypertrophy by Inhibiting Autophagy and Increasing Oxidative Stress. [Overexpression, myocardium]
● J Cell Mol Med. (IF=4.486). Lei W，et al. (2021). MARCH5 restores endothelial cell function against ischaemic/hypoxia injury via Akt/eNOS pathway. [Overexpression, myocardium]
● J Biol Chem. (IF=4.238). Zhang Z，et al. (2021). The adaptor protein GIPC1 stabilizes the scavenger receptor SR-B1 and increases its cholesterol uptake. [Overexpression/Knockdown, liver]
● J Anim Sci Biotechnol. (IF=4.167). Liu J, et al. (2021). Comprehensive evaluation of the metabolic effects of porcine CRTC3 overexpression on subcutaneous adipocytes with metabolomic and transcriptomic analyses. [Overexpression, adipocytes]
● Aging. (IF=4.831). Chen Y, et al. (2020). Mitophagy impairment is involved in sevoflurane-induced cognitive dysfunction in aged rats. [Autophagy dual-label, postoperative cognitive dysfunction]
● Elife Tool. (IF=7.08). Wu L, et al. (2019). PARIS, an optogenetic method for functionally mapping gap junctions. [Peking University, Ad-CMV-pHluorinCAAX, gap junction probe]
● Cell Death Dis. (IF=6.304). Su Y, et al. (2019). MicroRNA-181a-5p and microRNA-181a-3p cooperatively restrict vascular inflammation and atherosclerosis. [Zhongshan Ophthalmic Center, Sun Yat-sen University & Zhongshan School of Medicine, Sun Yat-sen University, Ad-TAB2 & Ad-NEMO HUVECs, atherosclerosis]
● EBioMedicine. (IF=5.736). Wang K, et al. (2019). TGF-beta1/p65/MAT2A pathway regulates liver fibrogenesis via intracellular SAM. [Taizhou Hospital Affiliated to Wenzhou Medical University, Ad-p65 & Ad-EV, liver fibrosis]
● Arthritis Res Ther. (IF=4.103). Zeng J, et al. (2019). Interferon-alpha exacerbates neuropsychiatric phenotypes in lupus-prone mice. [Renji Hospital, Shanghai Jiao Tong University School of Medicine, Adv-IFN-α & Adv-ctrl, systemic lupus erythematosus]
● Oncogene. (IF=7.971). Yu M, et al. (2018). Circadian regulator NR1D2 regulates glioblastoma cell proliferation and motility. [Peking University Shenzhen Graduate School, Ad-AXL, glioblastoma]
● Cell Death Discov. (IF=4.114). Zhang SQ, et al. (2018). Oleanolic acid enhances neural stem cell migration, proliferation, and differentiation in vitro by inhibiting GSK3beta activity. [Hong Kong Baptist University, Ad-GSK3β (S9A), neural stem cells NSCs]
● Int J Mol Med. (IF=3.098). Zhang L, et al. (2018). Anti-inflammatory effects of Lefty-1 in renal tubulointerstitial inflammation via regulation of the NF-kappaB pathway. [Team of Zhang Jie, Renmin Hospital of Wuhan University, Ad-Lefty-1, renal inflammation]
● Redox Biol. (IF=9.986). Jin Q, et al. (2018). DUSP1 alleviates cardiac ischemia/reperfusion injury by suppressing the Mff-required mitochondrial fission and Bnip3-related mitophagy via the JNK pathways. [Chinese PLA General Hospital, Ad-DUSP1 & Ad-ctrl, cardiac ischemia/reperfusion injury]
● Cell Physiol Biochem. (IF=5.5). Wang Y, et al. (2018). Inhibition of Histone Deacetylases Prevents Cardiac Remodeling After Myocardial Infarction by Restoring Autophagosome Processing in Cardiac Fibroblasts. [The Second Affiliated Hospital of Zhejiang University School of Medicine, Ad-mCherry-GFP-LC3, cardiac remodeling]
● Brain, Behavior, and Immunity. (IF=6.633). Zhou Y.T, et al. (2017). Interleukin-1β impedes oligodendrocyte progenitor cell recruitment and white matter repair following chronic cerebral hypoperfusion. [Zhejiang University, Ad-IL-1R1-RFP & Ad-RFP, subcortical ischemic vascular dementia SIVD]
● J Pharmacol Sci. (IF=2.835). Li J, et al. (2016). PKCζ interacts with STAT3 and promotes its activation in cardiomyocyte hypertrophy. [Sun Yat-sen University, Ad-PKCζ & Ad-GFP, cardiac hypertrophy]
● Arthritis Rheumatol. (IF=9.586). Han X, et al. (2016). MicroRNA-130b Ameliorates Murine Lupus Nephritis Through Targeting the Type I Interferon Pathway on Renal Mesangial Cells. [Shanghai Jiao Tong University School of Medicine, Ad-IFNα5, lupus nephritis]
● Sci Rep. (IF=3.998). Zhang H, et al. (2016). Endogenous sulfur dioxide is a novel adipocyte-derived inflammatory inhibitor. [Peking University First Hospital, Ad-AAT1 3T3-L1 cell, chronic adipose tissue inflammation]
● Mol Cell Biol. (IF=3.611). Wu C, et al. (2016). Phosphatidylinositol 3-Kinase/Akt Mediates Integrin Signaling To Control RNA Polymerase I Transcriptional Activity. [Southern University of Science and Technology, Ad-Cre, RNA polymerase I transcriptional activity]

Gene Silencing
● Cell Death Discovery (IF=6.1). Wei X, et.al. (2024). Tert promotes cardiac regenerative repair after MI through alleviating ROS-induced DNA damage response in cardiomyocyte. [Nanfang Hospital, Southern Medical University, ADV-shTert, ADV-sh-NC, cardiac regeneration]
● Molecular Metabolism (IF 8.1). Li J, et.al. (2024). Tyrosine-phosphorylated DNER sensitizes insulin signaling in hepatic gluconeogenesis by inducing proteasomal degradation of TRB3. [Renmin Hospital of Wuhan University, Ad-U6-shDNER, Ad-U6-shRNA control, hepatic gluconeogenesis]
● ACS Applied Materials & Interfaces（IF 9.5）. Yu KX.（2023）. Cancer-Erythrocyte Membrane-Mimicking Fe₃O₄ Nanoparticles and DHJS for Ferroptosis/ Immunotherapy Synergism in Tumors. [Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei University of Science and Technology, Zhongnan Hospital of Wuhan University, Ad-shRNA-Nrf2, Ad-shRNA-con, HOS cells (human osteosarcoma cells), MOI 50, osteosarcoma]
● Pharmacol Res.（IF=10.334）. Dong Y, et.al. (2022). Blocking the cytohesin-2/ARF1 axis by SecinH3 ameliorates osteoclast-induced bone loss via attenuating JNK-mediated IRE1 endoribonuclease activity. [Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Ad-4in1-shCytohesin-1; Ad-4in1-shCytohesin-2; Ad-4in1-shCytohesin-3; Ad-4in1-shNC, osteoporosis]
● Mol Ther. (IF=12.910). Zheng H, et al. (2022). CircRNA Samd4 induces cardiac repair after myocardial infarction by blocking mitochondria-derived ROS output. [Southern Medical University, Ad-shcircSamd4 & Ad-NC, myocardial infarction]
● Biomedicine & Pharmacotherapy.（IF=7.419）. Hong Q, et.al. (2022). Trimethylamine-N-oxide (TMAO) promotes balloon injury-induced neointimal hyperplasia via upregulating Beclin1 and impairing autophagic flux. [Zhujiang Hospital, Southern Medical University, Ad-shBeclin1 & Ad-shNC, vascular remodeling]
● Journal of Cellular and Molecular Medicine. (IF=4.486). Wang, et al. (2020). Inhibition of PFKFB3 suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss. [Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, murine PFKFB3 Adenoviruses-4 in 1 shRNA-GFP, bone marrow-derived macrophages BMMs, MOI=50, osteoclast-related diseases]
● EBioMedicine. (IF=5.736). Li, et al. (2019). Inhibition of AZIN2-sv induces neovascularization and improves prognosis after myocardial infarction by blocking ubiquitin-dependent talin1 degradation and activating the Akt pathway. [Nanfang Hospital, Southern Medical University, AZIN2-sv Adenoviruses-4 in 1 shRNA-GFP, human umbilical vein endothelial cells HUVECs, MOI=100, neovascularization]
● Bone. (IF=4.147). Zhao, et al. (2018). YAP1 is essential for osteoclastogenesis through a TEADs-dependent mechanism. [Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, murine YAP1 Adenoviruses-4 in 1 shRNA-GFP, bone marrow-derived macrophages BMMs & RAW264.7 cells, osteoclastogenesis]
● Cardiovascular Research. (IF=8.168). Li, et al. (2018). Loss of AZIN2 splice variant facilitates endogenous cardiac regeneration. [Nanfang Hospital, Southern Medical University, AZIN2-sv Adenoviruses-4 in 1 shRNA-GFP, cardiomyocytes CMs, MOI=100 & rat myocardial injection, cardiac regeneration]
● Br J Pharmacol. (IF=6.304). Ma Z.G, et al. (2016). Protection against cardiac hypertrophy by geniposide involves the GLP-1 receptor / AMPKalpha signalling pathway. [Renmin Hospital of Wuhan University, Ad-shAMPKα2, cardiac hypertrophy]
● Clin Sci. (IF=5.223). Ling Y, et al. (2016). Polydatin post-treatment alleviates myocardial ischaemia/reperfusion injury by promoting autophagic flux. [Zhujiang Hospital, Southern Medical University, Ad-sh-Beclin1&Ad-NC, myocardial ischemia/reperfusion injury]
● Int J Biol Sci. (IF=4.858). Ma Z G, et al. (2016). Asiatic Acid Protects against Cardiac Hypertrophy through Activating AMPKalpha Signalling Pathway. [Renmin Hospital of Wuhan University, Ad-shAMPKα2, cardiac hypertrophy]

Gene Editing
● Nat Commun. (IF=12.121). Fu R, et al. (2020). Endothelial ZEB1 promotes angiogenesis-dependent bone formation and reverses osteoporosis. [China Pharmaceutical University, Ad-βGal & Ad-Cre, osteoporosis]
● Cancer Sci. (IF=4.966). Wang X, et al. (2020). Targeting RNA helicase DHX33 blocks Ras-driven lung tumorigenesis in vivo. [Southern University of Science and Technology, Ad-LacZ & Ad-Cre, lung cancer]
● Int. J. Mol. Sci. (IF=4.556). Xu, et al. (2020). Effective MSTN Gene Knockout by AdV-Delivered CRISPR/Cas9 in Postnatal Chick Leg Muscle. [Shanghai Jiao Tong University, AdV-CRISPR system(pAdM-U6-gRNA1-U6-gRNA2-CMV-spCas9), chicken embryonic fibroblasts DF-1, MOI=1000 & chicken intramuscular injection, growth and development of chicken skeletal muscle]
Lentivirus

Dual-Reporter Lentiviral Vectors
● ACS Nano. (IF=18.027). ChunHua Zhao, et.al. (2023). Near-Infrared Phototheranostic Iron Pyrite Nanocrystals Simultaneously Induce Dual Cell Death Pathways via Enhanced Fenton Reactions in Triple-Negative Breast Cancer. [Sun Yat-sen University Cancer Center, Tokai University, LV-EF1a-luciferase-CMV-GFP-P2A-Puro, triple-negative breast cancer]

Overexpression

● Nature Communications (IF 14.7). Chen et.al. (2024). The lipid-metabolism enzyme ECI2 reduces neutrophil extracellular traps formation for colorectal cancer suppression. [Team of Li Xianong, Southern Medical University, colorectal cancer]
● Journal of Advanced Research (IF 11.4). Huang XG. (2024). Exploitation of enhanced prime editing for blocking aberrant angiogenesis. [Shenzhen Eye Hospital, NILV-LV5, NILV-LV6, NILVs-PE6x-VEGFR2, NILVs-PE6x-lacZ, retinal angiogenesis]
● International Journal of Biological Sciences (IF 8.2). Lu F, et.al. (2024). Hypoxic tumor-derived exosomal miR-4488 induces macrophage M2 polarization to promote liver metastasis of pancreatic neuroendocrine neoplasm through RTN3/FABP5 mediated fatty acid oxidation. [The First Affiliated Hospital of Nanjing Medical University, miR-4488 overexpression and knockdown lentiviral vectors, pancreatic neuroendocrine tumor]
● Cancer Letters (IF 9.1). Meng HY. (2024). YBX1 promotes homologous recombination and resistance to platinum-induced stress in ovarian cancer by recognizing m5C modification. [The First Affiliated Hospital of Nanjing Medical University, LV-CMV-YBX1, LV-CMV-shYBX1, ovarian cancer]
● Clin. Transl. Med. (IF 7.9). Guan X. (2024). Inhibition of HDAC2 sensitises antitumour therapy by promoting NLRP3/GSDMD-mediated pyroptosis in colorectal cancer. [Harbin Medical University Cancer Hospital, PLent-Puro-CMV-NLRP3 lentiviral vector, colorectal cancer]
● Oncogene (IF 8.0). Wei et.al. (2024). The splicing factor WBP11 mediates MCM7 intron retention to promote the malignant progression of ovarian cancer. [Team of Song Kun / Li Yingwei, Qilu Hospital of Shandong University, ovarian cancer]
● Cell Death & Disease (IF 9.0). Yao Y, et.al. (2024). Pyruvate dehydrogenase kinase 1 protects against neuronal injury and memory loss in mouse models of diabetes. [The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Lenti-PDK1, Lenti-GFP, diabetic neuropathy]
● Cancer Immunology Research (IF 10.1). Wang et.al. (2023). Combination anti-PD-1 and electroacupuncture induces a potent anti-tumor immune response in microsatellite-stable colorectal cancer. [Team of Zheng Tongsen, Harbin Medical University, pLent-Puro-CMV–luciferase, colorectal cancer]
● Journal of Experimental & Clinical Cancer Research (IF 11.3). Xie et.al. (2023). Gastric cancer-derived LBP promotes liver metastasis by driving intrahepatic fibrotic pre-metastatic niche formation. [The First Affiliated Hospital of Nanjing Medical University, LV-LBP, LV-shLBP, LV-TLR4, LV-NC, LV-GFP, gastric cancer liver metastasis]
● Cell Death & Bioactive Materials (IF 18.9). Wu et.al. (2024). Construction of functional neural network tissue combining CBD-NT3-modified linear-ordered collagen scaffold and TrkC-modified iPSC-derived neural stem cells for spinal cord injury repair. [Xiangya Hospital of Central South University, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, jointly with Beijing Institute of Pharmacology and Toxicology, Lv-TrkC, spinal cord injury repair]
● Cellular and Molecular Life Sciences. (IF 8.0). Song et.al. (2023). FKBP5 deficiency attenuates calcium oxalate kidney stone formation by suppressing cell–crystal adhesion, apoptosis and macrophage M1 polarization via inhibition of NF-κB signaling. [Renmin Hospital of Wuhan University, Institute of Technological Sciences, Wuhan University, AAV knockdown vectors, lentiviral overexpression and knockdown vectors, kidney]
● Cellular & Molecular Biology Letters. (IF 8.3). Kuang Xiangqin. (2023). Peptidase inhibitor (PI16) impairs bladder cancer metastasis by inhibiting NF-κB activation via disrupting multiple-site ubiquitination of NEMO. [Affiliated Cancer Hospital of Guangzhou Medical University, Lv-PI16, Lv-shRNA-PI16, bladder cancer (BLCA) cells]
● Cell Death Discovery. (IF 7.0). Zhang et.al. (2023). Disruption of RCAN1.4 expression mediated by YY1/HDAC2 modulates chronic renal allograft interstitial fibrosis. [The First Affiliated Hospital of Nanjing Medical University, AAV lentiviral overexpression vectors AAV9-RCAN1.4, LV-RCAN1.4, LV-YY1, kidney]
● Death and Disease. (IF 9.685). Xie XF. (2023). BACH1-induced ferroptosis drives lymphatic metastasis by repressing the biosynthesis of monounsaturated fatty acids. [Chinese Academy of Medical Sciences & Peking Union Medical College, LV-BACH1, LV-shBACH1, esophageal squamous cell carcinoma]
● Cancer Immunology, Immunotherapy. (IF 6.63). Wu PT. (2023). LILRB2-containing small extracellular vesicles from glioblastoma promote tumor progression by promoting the formation and expansion of myeloid‑derived suppressor cells. [The Second Affiliated Hospital of Soochow University & Shanghai Huashan Hospital, LV-pirb, LV-pirb-RFP, LV-nc, mouse glioblastoma GL261 cell line, MOI=50, glioblastoma]
● The Journal of Nutritional Biochemistry. (IF=5.6). Chen H, et.al. (2023). Autophagy and exosomes coordinately mediate quercetin's protective effects on alcoholic liver disease. [Huazhong University of Science and Technology, Lv-CYP2E1, alcoholic liver disease]
● Journal of Translational Medicine (IF=8.440). Bo Sun, et.al. (2023). AFAP1L1 promotes gastric cancer progression by interacting with VAV2 to facilitate CDC42-mediated activation of ITGA5 signaling pathway. [Hunan Provincial People's Hospital, AFAP1L1/VAV2/ITGA5 overexpression and knockdown lentiviruses, gastric cancer]
● Cell Death Discovery. (IF 7.0). Wang et.al. (2023). NSUN2 alleviates doxorubicin-induced myocardial injury through Nrf2-mediated antioxidant stress. [Hubei University of Medicine, NSUN2 lentiviral overexpression vector, heart]
● Journal of Experimental & Clinical Cancer Research. (IF 12.658). Huang et.al. (2023). Silencing LCN2 suppresses oral squamous cell carcinoma progression by reducing EGFR signal activation and recycling. [Sun Yat-sen Memorial Hospital, Sun Yat-sen University, LCN2 lentiviral overexpression and knockout vectors, oral squamous cell carcinoma]
● Molecular Cell. (IF 19.328). Jinzhou Huang et.al. (2023). SLFN5-mediated chromatin dynamics sculpt higher-order DNA repair topology. [School of Medicine, Tongji University, 53BP1 lentiviral knockdown and overexpression vectors, DNA repair]
● CNS Neurosci Ther. (IF=7.035). Miao Y, et.al. (2023). Anti-cancer effect of targeting fibroblast activation protein alpha in glioblastoma through remodeling macrophage phenotype and suppressing tumor progression. [Beijing Tiantan Hospital, Capital Medical University, Lv-FAP, glioblastoma]
● Oncogene. (IF=8.756). Chen H, et.al. (2022). Extracellular vesicles-transferred SBSN drives glioma aggressiveness by activating NF-κB via ANXA1-dependent ubiquitination of NEMO. [Guangzhou Medical University, Lv-SBSN, glioma]
● Cell Reports. (IF=9.995). Li H, et.al. (2022). β-hydroxybutyrate reduces reinstatement of cocaine conditioned place preference through hippocampal CaMKII-a β-hydroxybutyrylation. [West China Hospital, Sichuan University, pLenti-EF1α-CMV-CaMKII-α-Flag-GFP-2A-Puro; pLenti-EF1α-CMV-mutant CaMKII-α-Flag-GFP-2A-Puro, drug addiction]
● Cancer Letters. (IF=9.756). Wang Y, et.al. (2022). NNMT contributes to high metastasis of triple negative breast cancer by enhancing PP2A/MEK/ERK/c-Jun/ABCA1 pathway mediated membrane fluidity. [School of Medicine, Zhejiang University, Lv-NNMT & Lv-NNMTY20, breast cancer]
● J Exp Clin Cancer Res. (IF=12.658). Qiu S, et.al. (2022). Gastric cancer-derived exosomal miR-519a-3p promotes liver metastasis by inducing intrahepatic M2-like macrophage-mediated angiogenesis. [The First Affiliated Hospital of Nanjing Medical University, Lv-miR-519a-3p; Lv-miR-519a-3p-shRNA, gastric cancer liver metastasis]
● Cancer Lett. (IF=9.756). Wang Y, et.al. (2022). NNMT contributes to high metastasis of triple negative breast cancer by enhancing PP2A/MEK/ERK/c-Jun/ABCA1 pathway mediated membrane fluidity. [School of Medicine, Zhejiang University, pLenti-Pur-NNMT & pLenti-Pur-NNMT-Y20 & pLenti-Pur, breast cancer]
● EBioMedicine. (IF=11.205). Xiao RW, et.al. (2022). Rare POLN mutations confer risk for familial nasopharyngeal carcinoma through weakened Epstein-Barr virus lytic replication. [Sun Yat-sen University Cancer Center, Lv-POLN, nasopharyngeal carcinoma]
● Am J Med Sci. (IF=3.462). Luo R. (2022). CircRNA circ-MYBL2 absorbs precursor miR-92b in the nucleus to suppress its role in enhancing gastric cancer cell proliferation. [Chengdu People's Hospital, LV-circ-MYBL2, gastric cancer]
● Cancer Letters. (IF=9.756). Peng Nan, et.al. (2021). Tumor-stroma TGF-β1-THBS2 feedback circuit drives pancreatic ductal adenocarcinoma progression via integrin αvβ3/CD36-mediated activation of the MAPK pathway. [Chinese Academy of Medical Sciences & Peking Union Medical College, Lv-shPCK2-1 & Lv-shPCK2-2, pancreatic ductal adenocarcinoma]
● Cancer Letters. (IF=9.756). Xiaofeng Li, et.al. (2021). SETD8 stabilized by USP17 epigenetically activates SREBP1 pathway to drive lipogenesis and oncogenesis of ccRCC. [Qilu Hospital of Shandong University, pLent-U6-SETD8-GFP-Puro, clear cell renal cell carcinoma]
● J Immunother Cancer. (IF=12.469). Chao Liu, et.al. (2021). Blocking IL-17A enhances tumor response to anti-PD-1 immunotherapy in microsatellite stable colorectal cancer. [Harbin Medical University Cancer Hospital, pLent-Puro-CMV-miR-15b-5p & AAV-miR-15b-5p, colorectal cancer]
● Cell Death & Disease. (IF=6.304). Liu, et al. (2020). Long noncoding RNA SNHG12 promotes tumour progression and sunitinib resistance by upregulating CDCA3 in renal cell carcinoma. [Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, pLent-SNHG12-GFP-Puro & pLent-shSNHG12-GFP-Puro, renal cell carcinoma (RCC) cells]
● Cell Death & Disease. (IF=6.304). Liu, et al. (2020). Activation of STAT3 is a key event in TLR4 signaling-mediated melanoma progression. [Hong Kong Baptist University, lentivirus-CA-TLR4 fused with Myc and Flag tags, melanoma A375 cells]
● Cell Death & Disease. (IF=6.304). Wang, et al. (2019). LXRα promotes cell metastasis by regulating the NLRP3 inflammasome in renal cell carcinoma. [Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, pLent-LXRα-GFP-Puro & pLent-GFP-sh-LXRα-Puro, renal cell carcinoma (RCC) cells]
● Biochemical and Biophysical Research Communications. (IF=2.985). Zhu, et al. (2019). MicroRNA-506 inhibits the proliferation and invasion of mantle cell lymphoma cells by targeting B7H3. [Peking University Third Hospital, lent-miR-506, mantle cell lymphoma cells]
● Molecular Cancer. (IF=15.302). Tan, et al. (2019). PIWI-interacting RNA-36712 restrains breast cancer progression and chemoresistance by interaction with SEPW1 pseudogene SEPW1P RNA. [Sun Yat-sen University, pLent-Puro-GFP-piR-36712, human breast cancer MCF7 and ZR75-1 cells]
● Advanced Science. (IF=15.84). Lai, et al. (2018). A Modular Assembly of Spinal Cord–Like Tissue Allows Targeted Tissue Repair in the Transected Spinal Cord. [Sun Yat-sen University, pLent-EF1a-NT-3-Flag-CMV-GFP-P2A-Puro & pLent-EF1a-TrkC-Flag-CMV-GFP-P2A-Puro & pLent-EF1a-CNTF-Flag-CMV-GFP-P2A-Puro, neural stem cells (NSCs) & oligodendrocyte progenitor cells (OPCs), spinal cord injury]
● Theranostics. (IF=8.579). Mai, et al. (2018). PIWI-interacting RNA-54265 is oncogenic and a potential therapeutic target in colorectal adenocarcinoma. [Sun Yat-sen University, pLent-Puro-GFP-piR-54265, human colorectal cancer HCT116 and LoVo cells]
● Toxicology Letters. (IF=3.569). Yan, et al. (2018). Inhibitory Effect of PXR on Ammonia-induced Hepatocyte Autophagy via P53. [Union Hospital of Fujian Medical University, pLent-EF1a-PXR-CMV-GFP & pLent-U6-shPXR-GFP-Puro, human HL-7702 hepatocytes and human BEL-7404 hepatoma cells, hepatic autophagy]

Gene Knockout
● Journal of Advanced Research (IF 11.4). Jia et.al. (2025). Comprehensive multi-omics analyses exposes a precision therapy strategy that targets replication stress in hepatocellular carcinoma using WEE1 inhibition. [Academician Zheng Shusen, Song Penghong, The First Affiliated Hospital of Zhejiang University School of Medicine, human kinase gRNA lentiviral library, hepatocellular carcinoma]

Gene Silencing
● Journal of Advanced Research (IF 11.4). Xie et.al. (2024). Targeting ATM enhances radiation sensitivity of colorectal cancer by potentiating radiation-induced cell death and antitumor immunity. [Team of Ding Yi, Fang Yuan, Zhan Yizhi, Nanfang Hospital, Southern Medical University, Lv-shATM, Lv-shNC, colorectal cancer]
● Free Radical Biology and Medicine (IF=7.1). Ji R, et.al. (2024). Platycodin D ameliorates polycystic ovary syndrome-induced ovarian damage by upregulating CD44 to attenuate ferroptosis. [Renmin Hospital of Wuhan University, Lv-sh-CD44, Lv-sh-SLC7A11, Lv-sh-NC, polycystic ovary syndrome]
● Cell Communication and Signaling (IF 8.4). Li H, et.al. (2024). VDR promotes pancreatic cancer progression in vivo by activating CCL20-mediated M2 polarization of tumor associated macrophage. [Harbin Medical University Cancer Hospital, Lv-shVDR, pancreatic cancer]
● Cell Death and Differentiation (IF 12.4). Du Y, et.al. (2024). APE1 inhibition enhances ferroptotic cell death and contributes to hepatocellular carcinoma therapy. [Nanjing Normal University, Lv-shAPE1, hepatocellular carcinoma]
● Pharmacological Research (IF 9.3). Peng et.al. (2024). Gut Clostridium sporogenes-derived indole propionic acid suppresses osteoclast formation by activating pregnane X receptor. [Team of Li Feng, Guan Hanfeng, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, jointly with Dr. Feng Qian, College of Biological Engineering, Chongqing University, bone]
● Cell Death & Disease (IF 9.0). Sun Y, et.al. (2023). METTL3 promotes colorectal cancer progression through activating JAK1/STAT3 signaling pathway. [The Affiliated Cancer Hospital of Shandong First Medical University, Lv-METTL3-gRNA, Lv-METTL3-shRNA, Lv-YTHDF1-shRNA, colorectal cancer]
● BMC Biology (IF 5.4). You WJ. (2023). GADD45A regulates subcutaneous fat deposition and lipid metabolism by interacting with Stat1. [Zhejiang University, Lv-shGadd45a, Lv-shCtrl, mouse / porcine subcutaneous adipocytes, lipid metabolism]
● British Journal of Cancer. (IF 8.8). Zhang SJ. (2023). Chromatin accessibility uncovers KRAS-driven FOSL2 promoting pancreatic ductal adenocarcinoma progression through up-regulation of CCL28. [The Second Hospital of Shandong University & Qilu Hospital of Shandong University, shRNA interference lentiviruses targeting FOSL2 and KRAS, pancreatic ductal adenocarcinoma]
● Cellular and Molecular Life Sciences. (IF 8.0). Song et.al. (2023). FKBP5 deficiency attenuates calcium oxalate kidney stone formation by suppressing cell–crystal adhesion, apoptosis and macrophage M1 polarization via inhibition of NF-κB signaling. [Renmin Hospital of Wuhan University, Institute of Technological Sciences, Wuhan University, AAV knockdown vectors, lentiviral overexpression and knockdown vectors, kidney]
● Cell Death and Differentiation. (IF 12.067). Liang et.al. (2023). The TRAF2-p62 axis promotes proliferation and survival of liver cancer by activating mTORC1 pathway. [The First Affiliated Hospital of Zhejiang University School of Medicine, lentiviral knockdown vector pLent-shRNA-p62, liver]
● Metabolism Clinical and Experimental. (IF 13.934). Zhang et.al. (2022). ABCA1 deficiency-mediated glomerular cholesterol accumulation exacerbates glomerular endothelial injury and dysfunction in diabetic kidney disease. [West China Hospital, Sichuan University, pLent-RFP-shRNA-ABCA1 lentiviral knockdown vector, diabetes]
● Cell Death & Differentiation. (IF=12.067). Zhang G, et.al. (2023). Deficiency of cancer/testis antigen gene CT55 causes male infertility in humans and mice. [West China Second Hospital of Sichuan University, Wuhan University, pLent-shCT55, male infertility]
● Journal of Agricultural and Food Chemistry. (IF=5.895). Di Ran, et.al. (2023). Reactive Oxygen Species Control Osteoblast Apoptosis through SIRT1/PGC-1α/P53Lys382 Signaling, Mediating the Onset of Cd-Induced Osteoporosis. [Yangzhou University, Lv-SIRT1-shRNA knockdown lentivirus, osteoporosis]
● Angiogenesis. (IF=10.658). Weisi Lu, et.al. (2022). PDGFD switches on stem cell endothelial commitment. [Zhongshan Ophthalmic Center, Sun Yat-sen University, PDGFD overexpression and knockdown (4in1 shRNA) lentiviral vectors, vascular disease stem cell therapy]
● Journal of Cachexia, Sarcopenia and Muscle. (IF=12.063). You W, et.al. (2022). Growth arrest and DNA damage-inducible alpha regulates muscle repair and fat infiltration through ATP synthase F1 subunit alpha. [College of Animal Sciences, Zhejiang University, Lv-GADD45A-shRNA, intramuscular fat deposition]
● Neurosci Bull. (IF=5.271). Wang T, et.al. (2022). The Nucleus Accumbens CRH-CRHR1 System Mediates Early-Life Stress-Induced Sleep Disturbance and Dendritic Atrophy in the Adult Mouse. [Peking University Sixth Hospital, LV-CRH-shRNA, sleep disturbance]
● Cancer Letters. (IF=9.756). Zongpan Jing, et.al. (2021). Acetylation-induced PCK isoenzyme transition promotes metabolic adaption of liver cancer to systemic therapy. [Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Lv-PCK2-shRNA, liver cancer]
● Molecular Therapy: Nucleic Acids. (IF=10.183). Yu Zhang, et.al. (2021). Suppression of RNA editing by miR-17 inhibits the stemness of melanoma stem cells. [Zhejiang University, Lv-DOCK2-shRNA & psPAX & PMD2.G plasmids, melanoma stem cells]
● Cell Death and Disease. (IF=9.685). Xiaofang Chen, et.al. (2021). TCP1 increases drug resistance in acute myeloid leukemia by suppressing autophagy via activating AKT/mTOR signaling. [Union Hospital of Fujian Medical University, Lv-TCP1-shRNA, acute myeloid leukemia]
● Cell Death and Disease. (IF=9.685). Bo Sun, et.al. (2021). Programmed cell death 10 promotes metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma via PP2Ac-mediated YAP activation. [Xiangya Hospital of Central South University, Lv-PP2Ac-shRNA & Lv-PDCD10-shRNA, liver cancer]
● Cancer Letters. (IF=9.756). Fang-Jing Zhong, et.al. (2021). STMN2 mediates nuclear translocation of Smad2/3 and enhances TGFβ signaling by destabilizing microtubules to promote epithelial-mesenchymal transition in hepatocellular carcinoma. [Xiangya Hospital of Central South University, STMN2 3-in-1 shRNA lentivirus, liver cancer]
● Bioact Mater. (IF=14.593). Liu Y, et.al. (2021). DNA aptamer S11e recognizes fibrosarcoma and acts as a tumor suppressor. [Hunan University, Diablo/SMAC 3-in-1 shRNA lentivirus, fibrosarcoma]
● Cell Death & Disease. (IF=6.304). You, et al. (2020). GADD45α drives brown adipose tissue formation through upregulating PPARγ in mice. [Zhejiang University, Lenti-sh-Gadd45a in BAT cells & Ad-Gadd45a in SVF cells, obesity]
● Journal of Neuroinflammation. (IF=5.793). Zeng, et al. (2019). Lentivirus-mediated downregulation of α-synuclein reduces neuroinflammation and promotes functional recovery in rats with spinal cord injury. [Peking University Third Hospital, LV-SNCA-shRNA, spinal cord injury]
● Cell Discovery. (IF=6.255). Liao, et al. (2019). USP10 modulates the SKP2/Bcr-Abl axis via stabilizing SKP2 in chronic myeloid leukemia. [Guangzhou Medical University, pLent-4in1shRNA (for USP10/SKP2)-GFP & pLent-EF1a-FH-CMV-GFP containing SKP2-CDS, SKP2 (S72A), CML cells, MOI=10, chronic myeloid leukemia (CML)]
● International Journal of Biological Sciences. (IF=4.858). Zheng, et al. (2019). Cathelicidin-related antimicrobial peptide protects against cardiac fibrosis in diabetic mice heart by regulating endothelial-mesenchymal transition. [The First Affiliated Hospital of Zhengzhou University, lentiviruses-shAMPKa1, myocardial injection, diabetic cardiomyopathy]
● Oncogene. (IF=7.971). Liao, et al. (2018). Growth arrest and apoptosis induction in androgen receptor-positive human breast cancer cells by inhibition of USP14-mediated androgen receptor deubiquitination. [Guangzhou Medical University, pLent-4in1shRNA (for human USP14 (NM-005151))-GFP, human breast cancer cells, MOI=10, androgen receptor-positive breast cancer]
● J Mol Cell Cardiol. (IF=4.133). Li, et al. (2017). TCONS_00075467 modulates atrial electrical remodeling by sponging miR-328 to regulate CACNA1C. [Qianfoshan Hospital of Shandong University, 4in1 shRNA lentivirus lenti-RNAi-TCONS_00075467, primary cardiomyocytes, atrial fibrillation (AF) electrical remodeling]

Autophagy
● International Journal of Molecular Sciences (IF=6.208). Yang D, et.al. (2023). Pharmacological Targeting of Bcl-2 Induces Caspase 3-Mediated Cleavage of HDAC6 and Regulates the Autophagy Process in Colorectal Cancer. [Chongqing University of Arts and Sciences, Lv-mCherry-GFP-LC3B, colorectal cancer]
Adeno-associated Virus (AAV) -Nervous System

客户文章-质粒篇
● npj Biofilms and Microbiomes (IF=9.2). Li X, et.al. (2025). TSP50 deficiency in neural stem cells aggravates colitis in mice by altering intestinal microbiome. [Northeast Normal University, AAV-PHP.eB-TSP50, colitis induced by TSP50 deficiency in neural stem cells]
● Science (IF=45.8). Zheng Y, et.al. (2025). In vivo multiplex imaging of dynamic neurochemical networks with designed far-red dopamine sensors. [Peking University, AAV9-hSyn-HaloDA1.0, AAV9-hsyn-hChR2(H134R)-mCherry, AAV9-EF1α-DIO-hChR2(H134R)-EYFP, AAV9-hSyn-NE2m, AAV9-hSyn-r5-HT1.0, development of far-red dopamine sensors]
● Neuron (IF=14.7). Shi Y, et.al. (2025). Non-image-forming photoreceptors improve visual orientation selectivity and image perception. [University of Science and Technology of China & Army Medical University & Shenzhen Institute of Advanced Technology & Tsinghua University, AAV2/2-EF1a-DIO-GFP-WPRE-pA, visual image perception]
● Nature Communications (IF 14.7). Wei et.al. (2025). A high-performance fluorescent sensor spatiotemporally reveals cell-type specific regulation of intracellular adenosine in vivo. [Prof. Jing Wang, School of Pharmaceutical Sciences, Peking University; Prof. Zhaofa Wu, Institute of Genetics and Developmental Biology, CAS; Prof. Yulong Li, School of Life Sciences, Peking University, AAV2/9-hSyn-HypnoS, AAV2/9-hSyn-HypnoS-mut, AAV5-GfaABC1D-HypnoS, AAV5-GfaABC1D-HypnoS-mut, neural]
● Nature Communications (IF 14.7). Chen et.al. (2024). Histone lactylation mediated by Fam172a in POMC neurons regulates energy balance. [Hu Cheng, Zhang Yi, Shanghai Sixth People’s Hospital, AAV-EF1α-DIO-Fam172a-EGFP, neural]
● Journal of Advanced Research (IF=11.4). Zhao et.al. (2024). Hippocampal dipeptidyl peptidase 9 bidirectionally regulates memory associated with synaptic plasticity. [Team of Prof. Qixin Zhou, Kunming Institute of Zoology, CAS, AAV2/9-hSyn-DPP9-FLAG, AAV2/9-hSyn-GFP-WPRA, AAV2/9-CMV-Cas13d-FLAG-U6-2x gRNA DPP9, AAV2/9-CMV-Cas13d-FLAG-U6-2x gRNA NC, neural]
● Acta Neuropathologica Communications (IF=6.2). Lian et.al. (2024). Protein phosphatase 2Cm-regulated branched-chain amino acid catabolic defect in dorsal root ganglion neurons drives pain sensitization. [Team of Lü Peilin, Li Tao, West China Hospital, Sichuan University, AAV9–hsyn-cre, neural]
● Advanced Science (IF=14.3). Zhu Y, et.al. (2024). Adenosine-Dependent Arousal Induced by Astrocytes in a Brainstem Circuit. [School of Brain Science and Brain Medicine, Zhejiang University, AAV2/5-GfaABC1D-hPMCA2w/b-mCherry, AAV2/5-GfaABC1D-mCherry, AAV2/9-hsyn-GRABAdo1.0, AAV2/9-hsyn-GRABAdo1.0mut, AAV2/9-hsyn-GRABATP1.0, AAV2/5-GfaABC1D-ChrimsonR-mCherry, sleep-wake regulation]
● Advanced Science (IF=14.3). Wang et.al. (2024). Endothelial Cells Mediated by STING Regulate Oligodendrogenesis and Myelination During Brain Development. [Team of Prof. Jianwei Jiao, University of Chinese Academy of Sciences; Team of Prof. Lei Chen, West China Hospital, Sichuan University; Team of Prof. Yuming Xu, The First Affiliated Hospital of Zhengzhou University, vascular endothelium, AAV.BI30-FDFT1]
● Nature (IF=50.5). Pascal S. Kaeser et.al. (2024). Dopamine dynamics are dispensable for movement but promote reward responses. [Harvard Medical School, AAV9-hSyn-GRABDA2m, dopamine dynamics]
● npj Parkinson's Disease (IF 6.7). Cao B et.al. (2024). PDCD4 triggers α-synuclein accumulation and motor deficits via co-suppressing TFE3 and TFEB translation in a model of Parkinson’s disease. [Shandong University, AAV9-α-syn, AAV9-siTFE3, AAV9-siTFEB, AAV9-PDCD4, AAV9-Ctrl, Parkinson’s disease]
● Cell Reports (IF 7.5). Li et.al. (2024). Pyruvate dehydrogenase complex E1 subunit α crotonylation modulates cocaine-associated memory through hippocampal neuron activation. [Team of Prof. Xiaobo Cen, West China Hospital, Sichuan University, AAV2/8-CaMKII-mutant PDHA1-Flag, neural]
● Journal of Neuroinflammation (IF 9.3). Zhang WY. (2024). Microglial AKAP8L: a key mediator in diabetes-associated cognitive impairment via autophagy inhibition and neuroinflammation triggering. [Jining No.1 People’s Hospital Affiliated to Shandong First Medical University, AAV9-U6-sh-AKAP8L, AAV9-U6-sh-NC, diabetes-associated cognitive impairment]
● Nature Neuroscience (IF 21.2). Chen et.al. (2024). Spatiotemporally selective astrocytic ATP dynamics encode injury information sensed by microglia following brain injury in mice. [Team of Prof. Miao Jing, Beijing Institute for Brain Research, neural]
● Cancer Cell (IF 50.3). Zhong et.al. (2024). Distinct roles of TREM2 in central nervous system cancers and peripheral cancers. [Team of Prof. Nu Zhang, The First Affiliated Hospital, Sun Yat-sen University; Team of Prof. Fan Bai, Peking University, AAV9-F4/80-TREM2-flag-p2A-GFP, glioblastoma]
● Environment International (IF 11.8). Lin JH. (2024). circADAMTS6 via stabilizing CAMK2A is involved in smoking-induced emphysema through driving M2 macrophage polarization. [Nanjing Medical University, AAV9-F4/80-miR30.shRNA-circADAMTS6, nasal instillation 100 μL (5 × 10^11 VP), once weekly for 2 weeks, emphysema]
● Neuron (IF 16.2). Feng JS. (2024). Monitoring norepinephrine release in vivo using next-generation GRABNE sensors. [Peking University, AAV9-hSyn-GRABNE2m/NE2h, AAV9-Ef1a-DIO-C1V1-YFP, AAV9-GRABNE1m, AAV9-GRABNE2m, AAV9-GRABNE2h, AAV9-hSyn-NE2m, AAV9-hSyn-NEmut, second-generation norepinephrine sensors developed by Yulong Li Lab]
● Molecular Psychiatry (IF 13.437). Wang CS. (2023). Targeting PDK2 rescues stress-induced impaired brain energy metabolism. [Jining No.1 People’s Hospital Affiliated to Shandong First Medical University, AAV9-hSyn-sh-NC, AAV9-hSyn-sh-GR, AAV9-hSyn-sh-PDK2, stereotaxic brain injection, depression]
● Nature Communications (IF 16.6). Zhan JB. (2023). GDF11 slows excitatory neuronal senescence and brain ageing by repressing p21. [School of Basic Sciences and Sir Run Run Shaw Hospital, Zhejiang University; Institute of Brain Science and Translational Research, Fudan University; Shenzhen BGI Academy of Life Sciences, AAV9-CaMKIIα-Cre-EGFP, AAV9-CaMKIIα-EGFP, stereotaxic brain injection, bilateral cingulate gyrus, neuronal senescence]
● Current Biology (IF=9.2). Xinli Xu et.al. (2024). Hypothalamic CRF neurons facilitate brain reward function. [Shenzhen Institute of Advanced Technology, CAS, AAV9-hSyn-DA4.4, reward]
● Acta Pharmacologica Sinica (IF 8.2). Cheng J. (2024). Disfunction of dorsal raphe nucleus-hippocampus serotonergic-HTR3 transmission results in anxiety phenotype of Neuroplastin 65-deficient mice. [Tongji University, AAV9-hSyn-TPH2-P2A-GFP, 8.89×10^13 V.G/mL; AAV9-hSyn-GFP, 7.71×10^13 V.G/mL; stereotaxic injection into DRN, 1 μL, 1.11×10^9 V.G, 0.2 μL/min]
● Cell Discovery (IF=33.5). Yang G et.al. (2024). TMEM63B channel is the osmosensor required for thirst drive of interoceptive neurons. [Model Animal Research Center, Nanjing University School of Medicine & The First Affiliated Hospital of Zhengzhou University & Nanjing Drum Tower Hospital, AAV2/5-hSyn-DIO-GCaMP6s-P2A-nls-dTomato-hGH-pA, AAV2/5-CamKIIα-Cre-P2A-mCherry-WPRE-hGH-pA, thirst]
● Developmental Cell (IF=11.8). Wang Y, et.al. (2023). BACH1 changes microglial metabolism and affects astrogenesis during mouse brain development. [Institute of Zoology, CAS, AAV9-F4/80-GFP-mir30shRNA (Bach1), AAV9-F4/80-GFP-mir30shRNA (control), brain development]
● iScience (IF 6.107). Xia Q, et.al. (2023). SENP3-mediated deSUMOylation of c-Jun facilitates microglia-induced neuroinflammation after cerebral ischemia and reperfusion injury. [Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, AAV2/6-U6-DIO-scramble control-EGFP, AAV2/6-U6-DIO-SENP3/shRNA-EGFP, ischemic stroke]
● Science (IF 56.7). Li Yulong. (2023). A tool kit of highly selective and sensitive genetically encoded neuropeptide sensors. [Peking University, AAV9-hSyn-CRF1.0, AAV9-hSyn-CRFmut, AAV9-hSyn-CCK1.0, AAV9-hSyn-EGFP-CAAX, AAV9-hSyn-SST1.0, neuropeptide sensors]
● Nature Methods (IF 48). Li Yulong. (2023). Improved green and red GRAB sensors for monitoring dopaminergic activity in vivo. [Peking University, AAV2/9-hSyn-gDA3m, AAV2/9-hSyn-gDA3h, AAV2/9-hSyn-gDA3mut, AAV2/9-hSyn-gDA2m, AAV2/9-hSyn-dLight1.3b, AAV2/9-hSyn-ACh3.0, AAV2/9-hSyn-eCB2.0, AAV2/9-hSyn-NE2m, dopamine sensors]
● JACC-Basic to Translational Science (IF 9.531). Zhu ZY. (2023). Deficiency of GDF-11 Accelerates TAC-Induced Heart Failure by Impairing Cardiac Angiogenesis. [The Second Affiliated Hospital, Zhejiang University School of Medicine, AAV9-cTnT-Myc-GDF-11, heart, tail vein injection, heart failure]
● Molecular Neurobiology (IF 5.68). Wang et.al. (2023). The circ_006573/miR‑376b‑3p Axis Advances Spinal Cord Functional Recovery after Injury by Modulating Vascular Regeneration. [Renji Hospital, Shanghai Jiao Tong University School of Medicine, AAV knockdown vector AAV-circ_006573-shRNA, neural]
● iScience (IF 6.107). Li Xiao. et.al. (2023). Interhemispheric cortical long-term potentiation in the auditory cortex requires heterosynaptic activation of entorhinal projection. [City University of Hong Kong, AAV-hSyn-CCK2.3, auditory cortex, stereotaxic injection, neuro-cortical plasticity]
● BMC Biology (IF=7.364). Wang Z, et.al. (2023). Neural ensembles in the murine medial prefrontal cortex process distinct information during visual perceptual learning. [University of Science and Technology of China, AAV9-CaMKlla-GCaMP6f, AAV2/9-CaMKIIa-hM4Di-mCherry, AAV2/9-CaMKIIa-mCherry, visual perceptual learning]
● The FASEB Journal (IF 5.834). Yang et.al. (2023). Netrin-1 attenuates cerebral ischemia/reperfusion injury by limiting mitochondrial ROS and Ca2+ levels via activation of AKT phosphorylation and mitochondrial m-AAA protease AFG3L2. [Shanghai Jiao Tong University School of Medicine, Ad-Netrin-1; Ad-Control; Ad-shNetrin-1; Ad-shControl; AAV-Netrin-1; AAV-Control; AAV-U6-shNetrin-1; AAV-U6-shControl, AAV and adenovirus overexpression and knockdown vectors, brain injury]
● Phytomedicine (IF 6.656). Ouyang et.al. (2023). Khellin as a selective monoamine oxidase B inhibitor ameliorated paclitaxel-induced peripheral neuropathy in mice. [Nanjing University of Chinese Medicine, AAV-MAOB-shRNA, AAV knockdown vector, neural]
● Lipocalin 2 in the Paraventricular Thalamic Nucleus Contributes to DSS‑Induced Depressive‑Like Behaviors. [Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, AAV-CMV-shLcn2, paraventricular thalamic nucleus (PVT), bilateral injection, depressive-like behaviors]
● Biomaterials (IF 15.304). Lai et.al. (2023). Tail nerve electrical stimulation promoted the efficiency of transplanted spinal cordlike tissue as a neuronal relay to repair the motor function of rats with transected spinal cord injury. [Zhongshan School of Medicine, CNTF, NT3, TrkC, AAV overexpression vectors, neural]
● iScience (IF 6.107). Mahadi Hasan, et.al. (2023). Chemogenetic activation of astrocytes promotes remyelination and restores cognitive deficits in visceral hypersensitive rats. [City University of Hong Kong, AAV8-GFAP-hM3D(Gq)-mCherry, cognitive deficits]
● Translational Psychiatry (IF 7.989). Ya-Xin Sun, et.al. (2023). The causal involvement of the BDNF-TrkB pathway in dentate gyrus in early-life stress-induced cognitive deficits in male mice. [Peking University Sixth Hospital, AAV2/9-CaMKIIa-Cre-P2A-GFP & AAV2/9-CaMKIIa-GFP, cognitive impairment]
● Neurosci. Bull. (IF 5.271). Si Yue-Qin, et.al. (2022). REEP1 Preserves Motor Function in SOD1G93A Mice by Improving Mitochondrial Function via Interaction with NDUFA4. [School of Basic Medicine, Shandong University, AAV1-hREEP1-Flag & AAV1-GFP, neurodegenerative diseases]
● Neuron (IF 18.688). Yang et.al. (2023). Ventral tegmental area astrocytes modulate cocaine reward by tonically releasing GABA. [Johns Hopkins University, Gabrd, AAV knockout vector, neural]
● CELL MOL BIOL LETT. (IF 8.702). Zhonglin Cai et.al. (2022). ALKBH5 in mouse testicular Sertoli cells regulates Cdh2 mRNA translation to maintain blood–testis barrier integrity. [Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, ALKBH5, AAV knockdown vector, blood-testis barrier]
● Cell Reports (IF 9.995). Li H, et.al. (2022). β-hydroxybutyrate reduces reinstatement of cocaine conditioned place preference through hippocampal CaMKII-a β-hydroxybutyrylation. [West China Hospital, Sichuan University, AAV2/9-CaMKII-α-EGFP-Flag; AAV2/9-mutant CaMKII-α-EGFP-Flag, drug addiction]
● NEURAL REGENERATION RESEARCH (IF 6.058). Shu Liu, et.al. (2022). Knockdown of NADPH oxidase 4 reduces mitochondrial oxidative stress and neuronal pyroptosis following intracerebral hemorrhage. [Zhujiang Hospital, Southern Medical University, AAV9-shRNA-NOX4 and AAV9-CON, therapeutic target for intracerebral hemorrhage]
● BMC biology (IF 7.364). Shu Liu, et.al. (2022). Astrocytes in CA1 modulate schema establishment in the hippocampal-cortical neuron network. [City University of Hong Kong, AAV2/9-Ef1α-DIO-jGCaMp7s and AAV9-Syn-jGCaMp7s, CA1 astrocytes]
● Nat Biotechnol. (IF 68.164). Qian T, et.al. (2023). A genetically encoded sensor measures temporal oxytocin release from different neuronal compartments. [Peking University, AAV2/9-hSyn-OT1.0; AAV2/9-hSyn-OTmut; AAV2/9-hSyn-iGluSnFR (SF.iGluSnFR.A184V); AAV2/9-CMV-BFP2-P2A-TeNT; AAV2/9-hSyn-DIO-PSD95-EGFP, oxytocin neurotransmitter]
● Neuron (IF 18.688). Tian F, et.al. (2022). Core transcription programs controlling injury-induced neurodegeneration of retinal ganglion cells. [Harvard Medical School, mouse gRNA AAV library, neurodegenerative diseases]
● Cell Reports (IF 9.995). Zhong C, et.al. (2022). A neural circuit from the dorsal CA3 to the dorsomedial hypothalamus mediates balance between risk exploration and defense. [Shenzhen Institute of Advanced Technology, CAS, AAV9-CaMKII-eArchT-EYFP & AAV9-Ef1a-DIO-eArch3.0-EYFP, risk exploration-defense behavior]
● Journal of Neuroinflammation (IF 9.578). Fröhlich A, et.al. (2022). Neuronal nuclear calcium signaling suppression of microglial reactivity is mediated by osteoprotegerin after traumatic brain injury. [Ulm University, AAV9-hSyn-TNFRSF11b-P2A-mCherry, traumatic brain injury]
● Cell Rep. (IF 9.995). Qi X, et.al. (2022). A nociceptive neuronal ensemble in the dorsomedial prefrontal cortex underlies pain chronicity. [Peking University, AAV2/9-TRE3G-mCherry; AAV2/9-TRE3G-hM3DGq-mCherry, chronic pain]
● Nature (IF 69.504). Breton-Provencher, V. et al. (2022). Spatiotemporal dynamics of noradrenaline during learned behaviour. [Massachusetts Institute of Technology, AAV9-hSyn-DIO-GRABNE2m, learned behavior]
● Neurobiology of Stress (IF 7.142). Zhou H, et al. (2022). The antidepressant effect of nucleus accumbens deep brain stimulation is mediated by parvalbumin-positive interneurons in the dorsal dentate gyrus. [Tongji Medical College, Huazhong University of Science and Technology, AAV-EF1a-DIO-hM3Dq-mCherry & AAV-EF1a-DIO-hM4Di-mCherry, depression]
● CNS Neurosci Ther. (IF 7.035). Yun Y, et al. (2022). Targeting upregulated RNA binding protein RCAN1.1: a promising strategy for neuroprotection in acute ischemic stroke. [Qilu Hospital of Shandong University, AAV9-R1SR13 & AAV9-R-CON; Lenti-RCAN1.1L-GFP & Lenti-siRCAN1.1-GFP & Lenti-R1SR13-GFP & Lenti-CON, acute ischemic stroke]
● Neuron (IF 18.688). Chi S, et.al. (2022). Astrocytic Piezo1-mediated mechanotransduction determines adult neurogenesis and cognitive functions. [Tsinghua University, AAV2/9-GfaABC1D-ATP1.0, neurogenesis and cognition]
● Cell Rep. (IF 9.995). Dai B, et.al. (2022). Responses and functions of dopamine in nucleus accumbens core during social behaviors. [New York University, AAV9-hSyn-DIO-GRAB DA2m & AAV9-hSyn-loxP-GRAB DA2m -loxP, social behavior]
● Neurosci Bull. (IF 5.271). Wang T, et.al. (2022). The Nucleus Accumbens CRH-CRHR1 System Mediates Early-Life Stress-Induced Sleep Disturbance and Dendritic Atrophy in the Adult Mouse. [Peking University Sixth Hospital, AAV2/9-CAG-DIO-CRH-P2A-GFP, sleep disturbance]
● Mol Neurobiol. (IF 5.682). Chen B, et.al. (2022). Celsr3 Inactivation in the Brainstem Impairs Rubrospinal Tract Development and Mouse Behaviors in Motor Coordination and Mechanic-Induced Response. [Jinan University, AAV9-CMV-GFP & scAAV1-hSyn-Cre, spinal cord injury]
● Neuropharmacology (IF 5.273). Wang T, et.al. (2022). Malfunction of astrocyte and cholinergic inputs is involved in postoperative impairment of hippocampal synaptic plasticity and cognitive function. [Xuzhou Medical University, AAV-hSyn-GACh3.0, postoperative delirium]
● Signal Transduction and Targeted Therapy (IF 38.104). Ling Zhang, et.al. (2021). SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration. [Peking Union Medical College, Chinese Academy of Medical Sciences, AAV2-CMV-GFP & AAV9-CMV-GFP, blood-brain barrier]
● Nat Microbiol. (IF 30.964). Boqiang Sun, et.al. (2021). Regulation of host and virus genes by neuronal miR-138 favours herpes simplex virus-1 latency. [Zhejiang University, AAV-CAG-Foxc1, neurons]
● NATURE COMMUNICATIONS (IF 17.694). Qian Wang, et.al. (2021). Impaired calcium signaling in astrocytes modulates autism spectrum disorder-like behaviors in mice. [Southern Medical University, AAV8-GFAP-hM3Dq-mCherry and AAV9-GfaABC1D-ATP1.0, autism]
● Molecular Neurodegeneration (IF 18.879). Melanie Barth, et.al. (2021). Microglial inclusions and neurofilament light chain release follow neuronal α-synuclein lesions in long-term brain slice cultures. [German Center for Neurodegenerative Diseases, AAV-hA53T-αS, microglia]
● Protein Cell (IF 15.328). Xiaoyan Xu, et.al. (2021). Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model. [Zhejiang University, AAV-CAG-Hsc70-WT & AAV-CAG-Hsc70 S85A, Alzheimer’s disease]
● Cell Reports (IF 9.995). Zhuo Chen, et.al. (2021). Deficiency of ER Ca2+ sensor STIM1 in AgRP neurons confers protection against dietary obesity. [Huazhong University of Science and Technology, AAV-EF1a-DIO-EGFP, ER Ca2+ sensor in AgRP neurons]
● MOL THER-NUCL ACIDS. (IF=8.886). Qianqian Cao, et.al. (2022). Suppression of abnormal α-synuclein expression by activation of BDNF transcription ameliorates Parkinson’s disease-like pathology. [Jinan University, AAV9-hSyn-human SNCA, Parkinson’s disease]
● J Neuroinflammation. (IF=8.322). Huo S, et.al. (2021). Upregulation of TRPC5 in hippocampal excitatory synapses improves memory impairment associated with neuroinflammation in microglia knockout IL-10 mice. [Nankai University, AAV9-CaMKIIα-TRPC5 & AAV9-GFP, memory impairment]
● Nature Neuroscience (IF=20.071). Zhang, G.W., et al. (2021). Medial preoptic area antagonistically mediates stress-induced anxiety and parental behavior. [University of Southern California, AAVretro-Cre, retrograde neuronal labeling, anxiety and parental behavior]
● Nature Communications (IF=12.121). Xu, et.al. (2020). CircGRIA1 shows an age-related increase in male macaque brain and regulates synaptic plasticity and synaptogenesis. [Kunming Institute of Zoology, CAS, AAV9-shRNA(circGRIA1) & AAV9-shRNA(control), brain aging in male rhesus macaques]
● Science Advances (IF=13.116). Sun, et.al. (2020). Development of a CRISPR-SaCas9 system for projection- and function-specific gene editing in the rat brain. [Peking University, CRISPR-saCas9, gene editing in specific neuron populations of male SD rat brain]
● The Journal of Neuroscience (IF=5.673). Zingg B, et.al. (2020). Synaptic Specificity and Application of Anterograde Transsynaptic AAV for Probing Neural Circuitry. [University of Southern California, scAAV1 hSyn-Cre & AAV1-hSyn-Flp & AAVretro-hSyn-Cre & AAV1-EF1a-DIO-Flp-WPRE & AAVretro-hSyn-GFP-WPRE, anterograde monosynaptic tracing]
● Molecular Psychiatry (IF=12.384). Li, et.al. (2020). Programmed cell death 4 as an endogenous suppressor of BDNF translation is involved in stress-induced depression. [Shandong University, AAV9-CMV-mPdcd4-P2A-GFP, depression]
● Biological Psychiatry (IF=12.095). Zhang, et.al. (2020). Reduced neuronal cAMP in the nucleus accumbens damages blood-brain barrier integrity and promotes stress vulnerability. [China Pharmaceutical University, Dox-inducible AAV2/9-shRNA-Adcy5 or AAV2/9-shRNA, depression]
● Cell Reports (IF=8.109). Ma, et.al. (2019). Spontaneous Pain Disrupts Ventral Hippocampal CA1-Infralimbic Cortex Connectivity and Modulates Pain Progression in Rats with Peripheral Inflammation. [Peking University, AAV2 retro-hSyn-Cre-GFP & AAV2-CAG-DIO-BDNF-mCherry-3*flag, chronic pain]
● Cell (IF=38.637). Fan, et.al. (2019). Stress-Induced Metabolic Disorder in Peripheral CD4+ T Cells Leads to Anxiety-like Behavior. [Zhejiang University, AAV9-GFAP-GFP-miR30-shRNA(mAdora1) & AAV8-MBP-GFP-miR30-shRNA(mAdora1) & AAV8-MBP-GFP-miR30-shRNA(scramble), anxiety disorders]
● Neuron (IF=14.415). Feng, et.al. (2019). A Genetically Encoded Fluorescent Sensor for Rapid and Specific In Vivo Detection of Norepinephrine. [Peking University, AAV9-hSyn-NE1m & NE1h and AAV9-hsyn-tTA, norepinephrine sensor]
● Cell (IF=38.637). Sun, et.al. (2018). A Genetically Encoded Fluorescent Sensor Enables Rapid and Specific Detection of Dopamine in Flies, Fish, and Mice. [Peking University, AAV-hSyn-DA1m & DA1h, dopamine sensor]
● Behavioural Neurology (IF=2.093). Qu, et.al. (2018). MST1 Suppression Reduces Early Brain Injury by Inhibiting the NF-κB/MMP-9 Pathway after Subarachnoid Hemorrhage in Mice. [Department of Neurosurgery, Southwest Hospital, Third Military Medical University, MST1 AAV-4 in 1 shRNA-GFP, intracerebroventricular injection, subarachnoid hemorrhage]
● Neuron (IF=14.415). Zingg B, et.al. (2017). AAV-Mediated Anterograde Transsynaptic Tagging: Mapping Corticocollicular Input-Defined Neural Pathways for Defense Behaviors. [University of Southern California, AAV1-EF1a-DIO-Flp, anterograde monosynaptic tracing]
Adeno-associated Virus (AAV) -Circulatory System

客户文章-质粒篇
Heart
● Redox Biology (IF=10.7). Fu J, et.al. (2025). PDE4D inhibition ameliorates cardiac hypertrophy and heart failure by activating mitophagy. [School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, AAV9-cTNT-PDE4D5, AAV9-NC, heart failure]
● Nature Communications (IF 14.7). Wang et.al. (2025). Serpina3k lactylation protects from cardiac ischemia reperfusion injury. [Academician Hu Shengshou and Zhou Bingying, Fuwai Hospital, Chinese Academy of Medical Sciences, AAV9-FSP1-SA3K-WT, AAV9-FSP1-SA3K-K351R, cardiac ischemia-reperfusion injury]
● Cardiovascular Diabetology (IF=8.5). Wang R, et.al. (2024). Fibroblast growth factor 21 improves diabetic cardiomyopathy by inhibiting ferroptosis via ferritin pathway. [The First Affiliated Hospital of Jinan University, AAV9-FGF21, AAV9-GFP; AAV9-shFGF21, AAV9-Con, diabetic cardiomyopathy]
● Cardiovascular Research (IF=10.2). Che et.al. (2024). Cardiac tumour necrosis factor receptor-associated factor 7 mediates the ubiquitination of apoptosis signal-regulating kinase 1 and aggravates cardiac hypertrophy. [Team of Tang Qizhu, Renmin Hospital of Wuhan University, AAV9-cTNT-Traf7, AAV9-cTNT-GFP, cardiac hypertrophy]
● Experimental & Molecular Medicine (IF 9.5). Xian GP. (2024). Noncoding RNA regulates the expression of Krm1 and Dkk2 to synergistically affect aortic valve lesions. [Southern Medical University, AAV2-circHIPK3, AAV2-vector, aortic valve calcification]
● Cell Death and Disease (IF 8.1). Zhen J. (2024). Histone acetyltransferase Kat2a regulates ferroptosis via enhancing Tfrc and Hmox1 expression in diabetic cardiomyopathy. [Yu Haitao, First Hospital of Jilin University, AAV9-Alkbh5, AAV9-shAlkbh5; AAV9-Hmox1, AAV9-shHmox1; AAV9-Ythdf2, AAV-shYthdf2; AAV9-Kat2a, AAV9-shKat2a; AAV9-Trfc, AAV9-shTrfc; AAV9-GFP, AAV9-shNC, diabetic cardiomyopathy]
● Signal Transduction and Targeted Therapy (IF 40.8). Chen et.al. (2024). PBX/Knotted 1 homeobox-2 (PKNOX2) is a novel regulator of myocardial fibrosis. [Hu Shengshou / Li Xiangjie / Song Jiangping, Chinese Academy of Medical Sciences, myocardial fibrosis]
● Molecular Therapy (IF 12.4). Xie et.al. (2024). Nuclear AGO2 promotes myocardial remodeling by activating ANKRD1 transcription in failing hearts. [Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, AAV9-cTNT-AGO2 NLS, AAV9-cTNT-AGO2 NES, AAV9-cTNT-shAGO2, AAV9-cTNT-shANKRD1, heart failure]
● Advanced Science (IF 15.1). Guo et.al. (2023). NKRF in Cardiac Fibroblasts Protects against Cardiac Remodeling Post-Myocardial Infarction via Human Antigen R. [Qilu Hospital of Shandong University, AAV9-FSP1-NKRF, AAV9-FSP1-HuR, AAV9-FSP1-shHuR, Ad-NKRF, Ad-HuR, myocardial infarction]
● Advanced Science (IF 15.1). Cao XY. (2024). Role of Argininosuccinate Synthase 1-Dependent L-Arginine Biosynthesis in the Protective Effect of Endothelial Sirtuin 3 Against Atherosclerosis. [The Chinese University of Hong Kong, AAV8-HCRApoE-hAAT-mPCSK9, tail vein injection, 2.5×10^11 vg/mouse, atherosclerosis modeling]
● Acta Pharmaceutica Sinica B (IF 14.5). Yu W, et.al. (2023). Sorting nexin 3 exacerbates doxorubicin-induced cardiomyopathy via regulation of TFRC-dependent ferroptosis. [School of Pharmaceutical Sciences, Sun Yat-sen University, AAV9-shTFRC, AAV9-shNC, 3–5 intramyocardial injections, cardiomyopathy]
● Free Radical Biology and Medicine (IF 7.4). Zhang et.al. (2023). Frataxin inhibits the sensitivity of the myocardium to ferroptosis by regulating iron homeostasis. [School of Basic Medicine, Fourth Military Medical University; Xijing Hospital, Fourth Military Medical University, AAV and adenovirus overexpression vectors AAV9-cTNT-frataxin, Ad-Frataxin, heart]
● Journal of Molecular Medicine (IF 5.606). Shao SY. (2023). Never in mitosis gene A-related kinase 6 deficiency deteriorates diabetic cardiomyopathy via regulating heat shock protein 72. [The First Affiliated Hospital of Zhengzhou University, Ad-NEK6, MOI=50, cardiomyocytes, diabetic cardiomyopathy]
● Journal of Molecular Medicine (IF 5.606). Wu L, et.al. (2023). TRIM-containing 44 aggravates cardiac hypertrophy via TLR4/NOX4-induced ferroptosis. [The First Affiliated Hospital of Zhengzhou University, AAV9-cTnT-TRIM44, AAV9-cTnT-shTRIM44, cardiac hypertrophy]
● Oxidative Medicine and Cellular Longevity (IF 7.310). Li WJ, et.al. (2023). Cryptotanshinone Attenuated Pathological Cardiac Remodeling In Vivo and In Vitro Experiments. [Renmin Hospital of Wuhan University, AAV9-STAT3 & AAV9-GFP, cardiac remodeling]
● Cell Reports (IF 8.8). Zou J, et.al. (2023). Neddylation is required for perinatal cardiac development through stimulation of metabolic maturation. [Augusta University, AAV9-cTnT-Cre-WPRE, cardiac maturation]
● Cells (IF 7.666). Fangfang Li, et.al. (2022). KLF9 Aggravates Streptozotocin-Induced Diabetic Cardiomyopathy by Inhibiting PPARγ/NRF2 Signalling. [The Affiliated Hospital of Xuzhou Medical University, KLF9 AAV overexpression and knockdown vectors, diabetic cardiomyopathy]
● Cells (IF 7.666). Chen Z, et.al. (2022). TMEM43 Protects against Sepsis-Induced Cardiac Injury via Inhibiting Ferroptosis in Mice. [Wuhan Central Hospital, Tongji Medical College, Huazhong University of Science and Technology, AAV9-cTNT-TMEM43; AAV9-cTNT-shTMEM43, septic cardiomyopathy]
● Science Advances (IF 14.136). Bi HL, et.al. (2022). The deubiquitinase UCHL1 regulates cardiac hypertrophy by stabilizing epidermal growth factor receptor. [The Affiliated Hospital of Dalian Medical University, rAAV9-CMV-UCHL1 & rAAV9-CMV-GFP, cardiac hypertrophy]
● Acta Pharmaceutica Sinica B (IF 14.903). Wu X, et al. (2022). Dihydrotanshinone I preconditions myocardium against ischemic injury via PKM2 glutathionylation sensitive to ROS. [China Pharmaceutical University, AAV9-cTnT-shPKM2 & AAV9-cTnT-wildtype PKM2 & AAV9-cTnT-mutants PKM2, myocardial ischemia]
● Molecular Therapy (IF 12.910). Zheng H, et al. (2022). CircRNA Samd4 induces cardiac repair after myocardial infarction by blocking mitochondria-derived ROS output. [Southern Medical University, AAV9-circSamd4 & AAV9-NC, myocardial infarction]
● Frontiers in Cardiovascular Medicine (IF 7.419). Xin Huang, et.al. (2021). Suppression of abnormal α-synuclein expression by activation of BDNF transcription ameliorates Parkinson’s disease-like pathology. [Capital Medical University, AAV9-Sfrp5, myocardial infarction]
● Molecular Therapy-Nucleic Acids (IF 8.886). Xiang He, et.al. (2021). CircRNA Chordc1 protects mice from abdominal aortic aneurysm by contributing to the phenotype and growth of vascular smooth muscle cells. [Nanfang Hospital, Southern Medical University, AAV9-circChordc1-shRNA & AAV9-Scr, abdominal aortic aneurysm]
● Theranostics (IF 11.556). Hao Li, et.al. (2021). Lysyl hydroxylase 1 (LH1) deficiency promotes angiotensin II (Ang II)–induced dissecting abdominal aortic aneurysm. [Fuwai Hospital, Chinese Academy of Medical Sciences, AAV9-LH1-P2A-GFP & AAV9-GFP, abdominal aortic aneurysm]
● Journal of Molecular Medicine (Berl) (IF 4.599). Li F, et.al. (2021). Zinc finger and BTB domain-containing protein 20 aggravates angiotensin II-induced cardiac remodeling via the EGFR-AKT pathway. [The Affiliated Hospital of Xuzhou Medical University, AAV9-ZBTB20 & AAV9-shZBTB20, cardiac remodeling]
● Hypertension (IF 7.713). Liu, Wen, Li, et.al. (2020). Oleic Acid Attenuates Ang II (Angiotensin II)-Induced Cardiac Remodeling by Inhibiting FGF23 (Fibroblast Growth Factor 23). [Fuwai Hospital, Chinese Academy of Medical Sciences, AAV9-Fgf23 & AAV9-GFP, hypertensive cardiac remodeling]
● International Journal of Molecular Medicine (IF 3.098). Huang, et.al. (2019). Redd1 protects against post-infarction cardiac dysfunction by targeting apoptosis and autophagy. [Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, AAV9-Redd1 & AAV9-GFP, myocardial infarction (MI)]
● Frontiers in Pharmacology (IF 4.225). Shen, et.al. (2019). Downregulation of miR-146a Contributes to Cardiac Dysfunction Induced by the Tyrosine Kinase Inhibitor Sunitinib. [Hebei Medical University, AAV9-cTNT-GFP-miR-146a & AV-miR-146a, sunitinib-induced cardiac contractile dysfunction]
● Journal of Molecular and Cellular Cardiology (IF 4.133). Wu, et.al. (2019). The protective effect of high mobility group protein HMGA2 in pressure overload-induced cardiac remodeling. [Wuhan University, AAVs & Ads, cardiac remodeling]
● Biochemical and Biophysical Research Communications (IF 2.985). Yang, et.al. (2018). Vaspin alleviates myocardial ischaemia/reperfusion injury via activating autophagic flux and restoring lysosomal function. [Qilu Hospital of Shandong University, AAV-vaspin & Ad-RFP-GFP-LC3, heart]

Blood Vessels
● Acta Pharmaceutica Sinica B (IF=14.6). Li J, et.al. (2025). IMM-H007 promotes hepatic cholesterol and triglyceride metabolism by activating AMPKα to attenuate hypercholesterolemia. [Chinese Academy of Medical Sciences & Peking Union Medical College; University of Science and Technology of China, AAV-PCSK9, hypercholesterolemia and atherosclerosis]
● Acta Pharmaceutica Sinica B (IF=14.7). Ye W, et.al. (2025). Dihydromyricetin mitigates abdominal aortic aneurysm via transcriptional and posttranscriptional regulation of heme oxygenase-1 in vascular smooth muscle cells. [Jinan University & Guangdong Medical University, AAV2-SM22α-miR30-shHmox1, AAV2-SM22α-miR30-shCtrl, abdominal aortic aneurysm]
● Advanced Science (IF=14.3). Cui X, et.al. (2024). ZFP36 Regulates Vascular Smooth Muscle Contraction and Maintains Blood Pressure. [Qilu Hospital of Shandong University & The Second Affiliated Hospital of Harbin Medical University, AAV9-SM22α-shRGS2; AAV9-SM22α-shZFP36; AAV9-CTR shRNA, hypertension]
● Nature Communications (IF=14.7). Liu Y, et.al. (2025). E3 ubiquitin ligase RNF128 promotes Lys63-linked polyubiquitination on SRB1 in macrophages and aggravates atherosclerosis. [Qilu Hospital of Shandong University & School of Basic Medicine, Shandong University, AAV-PCSK9, atherosclerosis]
● Metabolism (IF 10.8). Liu et.al. (2024). Inhibiting IP6K1 confers atheroprotection by elevating circulating apolipoprotein A-I. [Fu Chenglai and Zhu Yi, Tianjin Medical University, AAV-mPCSK9, cardiovascular disease]
● Acta Pharmacologica Sinica (IF 6.9). Zheng et.al. (2024). Cytosolic DNA initiates a vicious circle of aging-related endothelial inflammation and mitochondrial dysfunction via STING: the inhibitory effect of Cilostazol. [Team of Liu Zhiping, School of Pharmacy, Jinan University; Team of Liu Peiqing, School of Pharmaceutical Sciences, Sun Yat-sen University, vascular endothelial cell senescence]
● Phytomedicine (IF 7.9). Zou J, et.al. (2024). Targeting the smooth muscle cell KEAP1-Nrf2-STING axis with pterostilbene attenuates abdominal aortic aneurysm. [Jinan University & Guangdong Medical University, AAV2-SM22α-shNrf2, AAV2-sh-control, abdominal aortic aneurysm]
● BMC Medicine (IF 9.3). Sheng Y, et.al. (2023). Tomo-seq identifies NINJ1 as a potential target for anti-inflammatory strategy in thoracic aortic dissection. [Guangzhou First People's Hospital; Fuwai Hospital, Chinese Academy of Medical Sciences, AAV9-U6-shNinj1, AAV9-NC, retro-orbital injection, thoracic aortic dissection]
● Cell Death & Disease (IF 9.0). Deng et.al. (2023). Smooth muscle liver kinase B1 inhibits foam cell formation and atherosclerosis via direct phosphorylation and activation of SIRT6. [Qilu Hospital of Shandong University, AAV knockdown vectors, AAV-PCSK9, atherosclerosis]
● Autophagy (IF=13.391). Chen Z, et.al. (2022). Vascular smooth muscle cell-derived hydrogen sulfide promotes atherosclerotic plaque stability via TFEB (transcription factor EB)-mediated autophagy. [Fuwai Hospital, Chinese Academy of Medical Sciences, rAAV8-HCRApoE/hAAT-D377Y-mPCSK9, atherosclerosis]
● Theranostics (IF 11.600). Hao Li, et.al. (2021). Lysyl hydroxylase 1 (LH1) deficiency promotes angiotensin II (Ang II)–induced dissecting abdominal aortic aneurysm. [Peking Union Medical College, AAV9-LH1 & AAV9-GFP, abdominal aortic aneurysm]
● Molecular Therapy: Nucleic Acids (IF=10.183). Xiang He, et.al. (2021). CircRNA Chordc1 protects mice from abdominal aortic aneurysm by contributing to the phenotype and growth of vascular smooth muscle cells. [Southern Medical University, AAV-circChrodc1-shRNA, abdominal aortic aneurysm]
● Biomedicine & Pharmacotherapy (IF=6.529). Wu Y, et.al. (2022). Endothelium-targeted delivery of PPARδ by adeno-associated virus serotype 1 ameliorates vascular injury induced by hindlimb ischemia in obese mice. [The Chinese University of Hong Kong, AAV-Vector & AAV-ICAM2-Ppard, hindlimb ischemia]
● Journal of Advanced Research (IF=10.479). Chak Kwong Cheng, et.al. (2022). SOX4 is a novel phenotypic regulator of endothelial cells in atherosclerosis revealed by single-cell analysis. [The Chinese University of Hong Kong, AAV-Vector & AAV-ICAM2-SOX4, atherosclerosis]
● Arteriosclerosis, Thrombosis, and Vascular Biology (IF 6.604). Zhao, et.al. (2019). ALDH2 (Aldehyde Dehydrogenase 2) Protects Against Hypoxia-Induced Pulmonary Hypertension. [Qilu Hospital of Shandong University, AAV2-SM22α-ALDH2 & AAV1-ICAM2-ALDH2, hypoxic pulmonary hypertension (HPH)]
● Journal of Molecular and Cellular Cardiology (IF 4.133). Sun, et.al. (2019). LncRNA H19 promotes vascular inflammation and abdominal aortic aneurysm formation by functioning as a competing endogenous RNA. [Nanfang Hospital, Southern Medical University, AAV9-H19, abdominal aortic aneurysm (AAA)]
● Journal of Cerebral Blood Flow & Metabolism (IF 5.681). Li, et.al. (2019). Overexpression of LH3 reduces the incidence of hypertensive intracerebral hemorrhage in mice. [Fuwai Hospital, Chinese Academy of Medical Sciences, AAV9-LH3-p2A-GFP, hypertensive intracerebral hemorrhage (ICH)]
● Arteriosclerosis, Thrombosis, and Vascular Biology (IF 6.604). Zhong, et.al. (2019). SM22α (Smooth Muscle 22α) Prevents Aortic Aneurysm Formation by Inhibiting Smooth Muscle Cell Phenotypic Switching Through Suppressing Reactive Oxygen Species/NF-κB (Nuclear Factor-κB). [Nanfang Hospital, Southern Medical University, AAV9-SM22α, abdominal aortic aneurysm (AAA)]
Adeno-associated Virus (AAV) -Digestive System

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Liver
● Advanced Science (IF=14.3). Yan H, et.al. (2025). Disturbing Cholesterol/Sphingolipid Metabolism by Squalene Epoxidase Arises Crizotinib Hepatotoxicity. [Zhejiang University, AAV8-TBG-NC, AAV8-TBG-shSqle, crizotinib-induced hepatotoxicity]
● Acta Pharmaceutica Sinica B (IF 14.7). Guo et.al. (2025). Diabetes-associated sleep fragmentation impairs liver and heart function via SIRT1-dependent epigenetic modulation of NADPH oxidase 4. [Team of Gu Junlian, Qilu Medical College, Shandong University, AAV8-TBG-CTL, AAV8-TBG-shNox4, AAV8-TBG-Sirt1, liver]
● Cell Reports (IF=7.5). Xue C, et.al. (2024). Nogo-B inhibition facilitates cholesterol metabolism to reduce hypercholesterolemia. [University of Science and Technology of China / Peking Union Medical College / Hefei University of Technology, AAV8-TBG-EGFP-miR30-shNogo-B, AAV8-TBG-EGFP-miR30-shControl, cholesterol metabolism]
● Nature Communications (IF 14.7). Yang X, et.al. (2024). FGF21 modulates immunometabolic homeostasis via the ALOX15/15-HETE axis in early liver graft injury. [Institute of Translational Medicine, Zhejiang University / Zhejiang Provincial People's Hospital, AAV8-TBG-Alox15 shRNA, liver transplantation injury]
● Journal of Hematology & Oncology (IF 29.5). Wang et.al. (2024). METTL16-SENP3-LTF axis confers ferroptosis resistance and facilitates tumorigenesis in hepatocellular carcinoma. [Team of Gao Yong / Li Yandong, Shanghai East Hospital, AAV8-TBG-Cre, hepatocellular carcinoma]
● Signal Transduction and Targeted Therapy (IF 40.8). Yan H. (2024). Ribosomal modification protein rimK-like family member A activates betaine-homocysteine S-methyltransferase 1 to ameliorate hepatic steatosis. [School of Basic Medical Sciences, Peking University; Peking University People's Hospital; Jilin University; First Hospital of Jilin University, AAV8-RIMKLA, AAV8-GFP, non-alcoholic fatty liver disease]
● Military Medical Research (IF 16.7). Hu CQ, et.al. (2024). PANX1-mediated ATP release confers FAM3A’s suppression effects on hepatic gluconeogenesis and lipogenesis. [School of Basic Medical Sciences, Peking University / Peking University People's Hospital / First Hospital of Jilin University, AAV8-CMV-FAM3A, AAV8-CMV-GFP, hepatic glucose and lipid metabolism]
● Cell Reports Medicine (IF 14.3). Zhu WZ. (2024). Activation of hepatic adenosine A1 receptor ameliorates MASH via inhibiting SREBPs maturation. [Shanghai University of Traditional Chinese Medicine, Huzhou Central Hospital, AAV8-TBG-A1R, AAV8-TBG-GFP, tail vein injection, 10^12 vg per mouse, liver MASH]
● Cell Death & Disease (IF 9.0). Li et.al. (2023). Gp78 deficiency in hepatocytes alleviates hepatic ischemia-reperfusion injury via suppressing ACSL4-mediated ferroptosis. [Team of Xu Xiao / Liu Zhikun / Wang Di, Zhejiang University School of Medicine, AAV8-TBG-gp78, liver]
● Journal of Lipid Research (IF=6.5). Yang Z, et.al. (2024). Histone demethylase KDM1A promotes hepatic steatosis and inflammation by increasing chromatin accessibility in NAFLD. [Renmin Hospital of Wuhan University, Gannan Medical University, AAV8-sgKDM1A, non-alcoholic fatty liver disease]
● Redox Biology (IF 11.4). Yuan JT. (2024). DDAH1 recruits peroxiredoxin 1 and sulfiredoxin 1 to preserve its activity and regulate intracellular redox homeostasis. [University of Chinese Academy of Sciences, Beijing Chaoyang Hospital, University of Mississippi, USA, AAV8-TBG-Prdx1, AAV8-TBG-GFP, tail vein injection, 1.1×10^12 vg/mouse]
● Journal of Translational Medicine (IF=7.4). Yang L, et.al. (2024). ANGPTL3 is a novel HDL component that regulates HDL function. [Beijing Luhe Hospital, Capital Medical University, AAV2/8-ANGPTL3, AAV2/8-vector, AAV2/8-shANGPTL3, AAV2/8-shNC, type 2 diabetes]
● Acta Pharmaceutica Sinica B (IF 14.5). Huang ZF, et.al. (2023). FGF4 protects the liver from immune-mediated injury by activating CaMKKb-PINK1 signal pathway to inhibit hepatocellular apoptosis. [First Affiliated Hospital of Wenzhou Medical University, AAV8-TBG-shFGFR4, AAV8-TBG-shPINK1, immune-mediated liver injury]
● Cell Death & Disease (IF 9.685). Tao X, et.al. (2023). Genetic deletion of phosphodiesterase 4D in the liver improves kidney damage in high-fat fed mice: liver-kidney crosstalk. [Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, AAV8-TBG-PDE4D, AAV8-GFP, non-alcoholic fatty liver disease]
● Acta Pharmaceutica Sinica B (IF 14.903). Shen X, et.al. (2023). Hepatic DDAH1 mitigates hepatic steatosis and insulin resistance in obese mice: Involvement of reduced S100A11 expression. [University of Chinese Academy of Sciences, AAV8-TBG-hDDAH1, AAV8-His; AAV8-shS100a11, AAV8-GFP; non-alcoholic fatty liver disease]
● International Journal of Molecular Sciences (IF 6.208). Chen et.al. (2023). Sleeve Gastrectomy Improves Hepatic Glucose Metabolism by Downregulating FBXO2 and Activating the PI3K-AKT Pathway. [Qilu Hospital of Shandong University, AAV overexpression vector AAV-TBG-FBXO2, liver]
● Molecular Therapy: Nucleic Acids (IF 8.8). Yang XS. (2023). PPM1H is down-regulated by ATF6 and dephosphorylates p-RPS6KB1 to inhibit progression of hepatocellular carcinoma. [Chinese Academy of Medical Sciences, AAV8-PPM1H, AAV8-control, tail vein injection, liver]
● Acta Pharmaceutica Sinica B (IF 14.903). Zhu et.al. (2023). The E3 ubiquitin ligase NEDD4-1 protects against acetaminophen-induced liver injury by targeting VDAC1 for degradation. [College of Veterinary Medicine, Jilin University, AAV overexpression and knockdown vectors, liver]
● Nature Communications (IF 17.694). Xiao et.al. (2023). Reduced hepatic bradykinin degradation accounts for cold-induced BAT thermogenesis and WAT browning in male mice. [Institute of Brain Science and Translational Research, Fudan University, PREP AAV overexpression vector, liver and adipose thermogenesis]
● Cell Biology and Toxicology (IF=6.819). Chen X, et.al. (2022). Activation of cDCs and iNKT cells contributes to triptolide-induced hepatotoxicity via STING signaling pathway and endoplasmic reticulum stress. [China Pharmaceutical University, AAV8-siSTING & AAV8-control, hepatotoxicity]
● Metabolism (IF=13.934). Yan H, et.al. (2022). FAM3A maintains metabolic homeostasis by interacting with F1-ATP synthase to regulate the activity and assembly of ATP Synthase. [School of Basic Medical Sciences, Peking University Health Science Center, AAV8-U6-shFOXD3 & AAV8-U6-GFP (pAV-3in1-shRNA-GFP), metabolic diseases]
● Hepatology (IF=17.298). Wang T, et.al. (2022). Cellular heterogeneity and transcriptomic profiles during intrahepatic cholangiocarcinoma initiation and progression. [Tongji Medical College, Huazhong University of Science and Technology & Xi'an Jiaotong University, AAV8-CRISPR/sgZmiz1 & AAV8-CRISPR/sgYbx1, intrahepatic cholangiocarcinoma]
● Cell Metabolism (IF=31.373). Wang Lin, et.al. (2021). Tripartite motif 16 ameliorates nonalcoholic steatohepatitis by promoting the degradation of phospho-TAK1. [Hepatobiliary Surgery Department, Xijing Hospital, Fourth Military Medical University, AAV8-TRIM16 & AAV8-GFP, non-alcoholic steatohepatitis]
● Cell Metabolism (IF=27.287). Wang L, et.al. (2021). Tripartite motif 16 ameliorates nonalcoholic steatohepatitis by promoting the degradation of phospho-TAK1. [Xijing Hospital, Fourth Military Medical University, AAV8-CMV-TRIM16 & AAV8-CMV-GFP, non-alcoholic steatohepatitis]
● Human Cell (IF=4.174). Chen S, et.al. (2021). Overexpression of ring finger protein 20 inhibits the progression of liver fibrosis via mediation of histone H2B lysine 120 ubiquitination. [People's Hospital Affiliated to Hangzhou Medical College, AAV8-TBG-RNF20, liver fibrosis]
● Proceedings of the National Academy of Sciences of the United States of America (PNAS) (IF=9.412). Zhang, et.al. (2020). Hepatic neddylation targets and stabilizes electron transfer flavoproteins to facilitate fatty acid β-oxidation. [Academy of Military Medical Sciences, PLA & Nankai University, AAV-DJ-CAG-Cre, glutaric aciduria type II (GA-II)]
● Journal of Hepatology (IF=20.582). She, et.al. (2019). PSMP/MSMP promotes hepatic fibrosis through CCR2 and represents a novel therapeutic target. [School of Basic Medical Sciences, Peking University, AAV8-hPSMP & null, liver fibrosis]
● Theranostics (IF=8.579). Liu, et.al. (2019). Suppression of YAP/TAZ-Notch1-NICD axis by bromodomain and extraterminal protein inhibition impairs liver regeneration. [Zhejiang University, AAV9-CMV-YAP, liver regeneration]
● Molecular Cell (IF=15.584). Wan, et.al. (2019). Pacer is a mediator of mTORC1 and GSK3-TIP60 signaling in regulation of autophagosome maturation and lipid metabolism. [Zhejiang University, AAV9-mCherry-GFP-LC3 and AAV9-Pacerwt-HA & Pacer2KR-HA & PacerS157A-HA & PacerS157D-HA, hepatic autophagy and lipid metabolism]
● Experimental Cell Research (IF=3.383). Li, et.al. (2018). Brg1 promotes liver fibrosis via activation of hepatic stellate cells. [Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, AAV8-shBrg1 or AAV8-GFP, liver fibrosis]
● Molecular Cell (IF=15.584). Wan, et.al. (2018). mTORC1-Regulated and HUWE1-Mediated WIPI2 Degradation Controls Autophagy Flux. [Zhejiang University, AAV9-shHUWE1 & shNC and AAV9-WIPI2 & WIPI2-S395A & WIPI2-S395D, hepatic autophagy]
● Molecular Cell (IF=15.584). Su, et.al. (2017). VPS34 Acetylation Controls Its Lipid Kinase Activity and the Initiation of Canonical and Non-canonical Autophagy. [Zhejiang University, AAV9-CMV-VPS34 & 3KR & 3KQ, hepatic autophagy]
● Proceedings of the National Academy of Sciences of the United States of America (PNAS) (IF=9.412). He, et.al. (2017). MicroRNA-351 promotes schistosomiasis-induced hepatic fibrosis by targeting the vitamin D receptor. [Second Military Medical University, AAV8-CMV-eGFP-miR-351-5p Sponge, schistosomiasis-induced liver fibrosis]

Esophagus
● Cell Reports (IF=8.8). Nan et.al. (2023). m6A demethylase FTO stabilizes LINK-A to exert oncogenic roles via MCM3-mediated cell-cycle progression and HIF-1α activation. [Team of Liu Zhihua / Li Yin, Chinese Academy of Medical Sciences, AAV-shLINK-A, AAV-shCtrl, esophageal cancer]
● Molecular Therapy (IF=12.910). Nan Y, et.al. (2022). HCP5 prevents ubiquitination-mediated UTP3 degradation to inhibit apoptosis by activating c-Myc transcriptional activity. [Cancer Hospital, Chinese Academy of Medical Sciences, AAV-shHCP5 & AAV-shCtrl, esophageal squamous cell carcinoma]

Stomach
● Cell Death & Disease (IF 9.0). Li YT, et.al. (2023). Targeting LGSN restores sensitivity to chemotherapy in gastric cancer stem cells by triggering pyroptosis. [Health Science Center, Shenzhen University, AAV9-shLGSN, AAV9-shNTC, gastric cancer]

Pancreas
● Cell Death & Disease (IF 8.1). Shao L, et.al. (2024). FXR-regulated COX6A2 triggers mitochondrial apoptosis of pancreatic β-cell in type 2 diabetes. [Health Science Center, Shenzhen University, AAV9-CMV-SaCas9-3xHA-U6-sgCox6a2, AAV9-vector, type 2 diabetes]
● Nature Communications (IF 16.6). Zhang H. (2024). ZDHHC20-mediated S-palmitoylation of YTHDF3 stabilizes MYC mRNA to promote pancreatic cancer progression. [Second Xiangya Hospital, Central South University; Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, AAV8-shZDHHC20, AAV8-shControl, intraperitoneal injection 100 μL/mouse, pancreatic cancer]
● Acta Pharmaceutica Sinica B (IF 14.5). Liu Y, et.al. (2023). A high-throughput Gaussia luciferase reporter assay for screening potential gasdermin E activators against pancreatic cancer. [China Pharmaceutical University, AAV-shGSDME, AAV-shC, intratumoral injection, pancreatic ductal adenocarcinoma]
● Cellular and Molecular Life Sciences (IF 9.207). Zhao Xingqi. (2023). Excessive iron inhibits insulin secretion via perturbing transcriptional regulation of SYT7 by OGG1. [Nanjing Normal University, AAV8-SYT7 & AAV8-null, intraductal pancreatic injection]
● iScience (IF 6.107). Guo et.al. (2023). Steroidogenic factor 1 protects mice from obesity-induced glucose intolerance via improving glucose-stimulated insulin secretion by beta cells. [First Affiliated Hospital, Sun Yat-sen University, AAV and adenovirus overexpression vectors, pancreas]
● Digestive Diseases and Sciences (IF=3.487). Yang Xiaoyu, et.al. (2021). MiR155 Disrupts the Intestinal Barrier by Inducing Intestinal Inflammation and Altering the Intestinal Microecology in Severe Acute Pancreatitis. [First Affiliated Hospital of Nanchang University, AAV9-miR155 and AAV9-miR155 sponge, severe acute pancreatitis]
● Nature Communications (IF 17.694). Cheng R, et.al. (2023). Circular RNA circGlis3 protects against islet β-cell dysfunction and apoptosis in obesity. [China Pharmaceutical University & Southeast University, AAV8-MIP (mouse insulin1 promoter)-circGlis3, diabetes]
● Cell Research (IF 46.297). Cheng R, et.al. (2022). A novel protein RASON encoded by a lncRNA controls oncogenic RAS signaling in KRAS mutant cancers. [First Affiliated Hospital, Sun Yat-sen University & Soochow University & Nanjing University, AAV9-shRNA-RASON & AAV9-shRNA-NC, KRAS-mutant cancers]

Intestine
● Clinical Cancer Research (IF 13.801). Ding et.al. (2023). A Tumor-suppressive Molecular Axis EP300/circRERE/miR-6837-3p/MAVS Activates Type I IFN Pathway and Antitumor Immunity to Suppress Colorectal Cancer. [First Affiliated Hospital of Xiamen University, AAV-CMV-circRNA-mCMV-copGFP AAV overexpression vector, cancer]
● Journal for ImmunoTherapy of Cancer (IF 12.461). Liu Chao, et.al. (2021). Blocking IL-17A enhances tumor response to anti-PD-1 immunotherapy in microsatellite stable colorectal cancer. [Cancer Hospital of Harbin Medical University, AAV-miR-15b-5p sponge, colorectal cancer]
● Cancer Letters (IF=9.756). Qiao Simiao, et.al. (2020). Arctigenin disrupts NLRP3 inflammasome assembly in colonic macrophages via downregulating fatty acid oxidation to prevent colitis-associated cancer. [China Pharmaceutical University, AAV9-CPT1 & AAV9-control, colitis-associated colorectal cancer]
Adeno-associated Virus (AAV) -Other Systems

客户文章-质粒篇
Metabolism
● Nature Cell Biology (IF 17.3). Chen et.al. (2025). Rpl12 is a conserved ribophagy receptor. [Team of Yi Cong and Zou Wei, Zhejiang University; Team of Feng Du, Guangzhou Medical University; Team of Huang Yunpeng, Hangzhou Institute for Advanced Study, UCAS; Team of Mei Kunrong, Tianjin University, rAAV9-RPL12-WT, rAAV9-RPL12 P3N-E21L, ribosome homeostasis]
● Nature Metabolism (IF 18.9). Zheng et.al. (2024). S-acylation of ATGL is required for lipid droplet homoeostasis in hepatocytes. [Team of Dante Neculai and Liu Wei, The Fourth Affiliated Hospital of Zhejiang University School of Medicine; Team of Brian Raught, University of Toronto, Canada; Team of Gregory D. Fairn, Dalhousie University, Canada, lipid metabolism]
● Circulation (IF 37.8). Zhan JB. (2023). Ago2 protects against diabetic cardiomyopathy via activating mitochondrial gene translation. [Department of Cardiology, Tongji Hospital, Huazhong University of Science and Technology, AAV9-cTNT-NLS-Ago2, AAV9-cTNT-NES-Ago2, AAV9-cTNT-COX8-Ago2, AAV9-cTNT-shRNA-Ago2, tail vein injection, diabetes]
● Metabolism (IF 9.8). Hu YT. (2023). Hepatocyte-secreted FAM3D ameliorates hepatic steatosis by activating FPR1-hnRNP U-GR-SCAD pathway to enhance lipid oxidation. [School of Basic Medical Sciences, Peking University Health Science Center; Peking University People's Hospital, AAV8-FPR1, AAV8-GFP, tail vein injection, hepatic lipid metabolism]
● Nature Communications (IF 17.694). Zhong et.al. (2023). Adipose-specific deletion of the cation channel TRPM7 inhibits TAK1 kinase-dependent inflammation and obesity in male mice. [The Sixth Affiliated Hospital, Sun Yat-sen University, AAV8-TAK1; AAV8-Vec; AAV8-Adipoq-Cre AAV overexpression vectors, obesity and metabolism]
● Acta Pharmaceutica Sinica B (IF 14.5). Tang WZ, et.al. (2023). Targeting Kindlin-2 in adipocytes increases bone mass through inhibiting FAS/PPARγ/FABP4 signaling in mice. [Southern University of Science and Technology & The First Affiliated Hospital of SUSTech, AAV-Rec2-CasRx-sgRNA-Kindlin-2, adipose]
● Protein & Cell (IF 15.328). Pu Maomao, et.al. (2023). ORP8 acts as a lipophagy receptor to mediate lipid droplet turnover. [School of Medicine, Zhejiang University, AAV9-ORP8-WT, AAV9-ORP8-T54A/S65A, AAV9-ORP8-LIRs-6A, AAV9-ORP5, lipophagy]

Bone
● Cell Death and Differentiation (IF 13.7). Liu C, et.al. (2024). Foxk1 promotes bone formation through inducing aerobic glycolysis. [Shenzhen People's Hospital, AAV9-Osterix-Foxk1, AAV9-Osterix-GFP, bone formation]
● Cell Communication and Signaling (IF 8.2). Sun K, et.al. (2024). IRF1 regulation of ZBP1 links mitochondrial DNA and chondrocyte damage in osteoarthritis. [Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, AAV9-shZBP1, AAV9-shGFP, osteoarthritis]
● Free Radical Biology and Medicine (IF 8.101). Kai Sun, et.al. (2023). JNK-JUN-NCOA4 axis contributes to chondrocyte ferroptosis and aggravates osteoarthritis via ferritinophagy. [Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, intra-articular injection of AAV9-NCOA4 & AAV9-GFP, osteoarthritis treatment]

Muscle
● Nature Metabolism (IF 18.9). Peng et.al. (2025). Cellular Feimin enhances exercise performance by suppressing muscle thermogenesis. [Team of Wang Yiguo, Tsinghua University, AAV9-cFeimin; AAV9-cFeimin 112/128T/A; AAV9-cFeimin 112/128T/D; AAV9-cFeimin 124/140R/D; AAV9-shcFeimin, muscle thermogenesis]
● Molecular Therapy (IF 12.4). Cataldi MP, et.al. (2023). Improved efficacy of FKRP AAV gene therapy by combination with ribitol treatment for LGMD2I. [Atrium Health Carolinas Medical Center, AAV9-MCK-FKRP, muscular dystrophy]
● Science Advances (IF 13.6). Jia M, et.al. (2023). ULK1-mediated metabolic reprogramming regulates Vps34 lipid kinase activity by its lactylation. [East China University of Science and Technology, rAAV-Vps34WT, rAAV-Vps342KR, rAAV-Ctrl, skeletal muscle homeostasis]
● Skeletal Muscle (IF 4.9). Witcher PC, et.al. (2023). Expression of Myomaker and Myomerger in myofibers causes muscle pathology. [Cincinnati Children's Hospital, AAV9-CMV-Myomerger, AAV9-GFP, muscle pathology]
● Biomedicine & Pharmacotherapy (IF 7.5). Wu Y, et.al. (2022). Endothelium-targeted delivery of PPARδ by adeno-associated virus serotype 1 ameliorates vascular injury induced by hindlimb ischemia in obese mice. [The Chinese University of Hong Kong, AAV1-ICAM2-Ppard, AAV1-control, diabetic vascular disease]
● JCI Insight (IF 8.0). Kwong JQ, et.al. (2018). The mitochondrial calcium uniporter underlies metabolic fuel preference in skeletal muscle. [Cincinnati Children's Hospital, AAV9-Cre, AAV9-GFP, skeletal muscle metabolism]

Intervertebral Disc
● Redox Biology (IF 10.787). Zhu Jian. (2023). The deubiquitinase USP11 ameliorates intervertebral disc degeneration by regulating oxidative stress-induced ferroptosis via deubiquitinating and stabilizing Sirt3. [Second Affiliated Hospital of Naval Medical University (Shanghai Changzheng Hospital), AAV-USP11 & AAV-Ctrl, intradiscal injection]

Ear
● Cell Reports (IF 9.995). Liu, et.al. (2022). Template-independent genome editing in the Pcdh15 av-3j mouse, a model of human DFNB23 nonsyndromic deafness. [Tsinghua University, AAV2/9-mCherry & AAV2/9-m-3j-gRNA1, hereditary deafness]

Eye
● Cell Reports Medicine (IF 14.3). Li CP, et.al. (2024). Lhx2 promotes axon regeneration of adult retinal ganglion cells and rescues neurodegeneration in mouse models of glaucoma. [Institute of Zoology, Chinese Academy of Sciences; Beijing Tongren Hospital, AAV2-CAG-PLAP, AAV2-CAG-CNTF, glaucoma neurodegeneration]
● Cell Death and Disease (IF 9). Li Y. (2023). TGR5 supresses cGAS/STING pathway by inhibiting GRP75-mediated endoplasmic reticulum-mitochondrial coupling in diabetic retinopathy. [Wuxi People's Hospital Affiliated to Nanjing Medical University, AAV8-shTGR5, AAV8-vector, 2μL intravitreal injection, diabetic retinopathy]
● Antioxidants (IF 7.675). Zhang F, et.al. (2023). Melatonin Alleviates Retinal Ischemia-Reperfusion Injury by Inhibiting p53–Mediated Ferroptosis. [Zhongshan Ophthalmic Center, Sun Yat-sen University, AAV2-p53 & AAV2-GFP, retinal ischemia-reperfusion]
● Computational and Structural Biotechnology Journal (IF 6.155). Zhang J, et.al. (2023). PDGF-D-induced immunoproteasome activation and cell-cell interactions. [Zhongshan Ophthalmic Center, Sun Yat-sen University & GZIBMS, Guangzhou Medical University, AAV-VMD2-PDGF-D & AAV-GFP, choroidal neovascularization]

Skin
● International Journal of Biological Sciences (IF 4.858). Wu, et.al. (2019). Metformin Promotes the Survival of Random-Pattern Skin Flaps by Inducing Autophagy via the AMPK-mTOR-TFEB signaling pathway. [The Second Affiliated Hospital of Wenzhou Medical University, AAV9-U6-shRNA (Prkaa1)-CMV-EGFP, random-pattern skin flap]

Kidney
● Cell Communication and Signaling (IF 8.9). Chen Y, et.al. (2025). Inhibition of tubular epithelial cells ferroptosis alleviates renal interstitial fibrosis by reducing lipid hydroperoxides and TGF-β/Smad signaling. [Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, AAV9-mGPX4, AAV9-vector, renal interstitial fibrosis]
● Free Radical Biology and Medicine (IF 7.1). Hu H, et.al. (2025). Dapagliflozin Attenuates Diabetes-Induced Podocyte Lipotoxicity via ERRα-Mediated Lipid Metabolism. [Renmin Hospital of Wuhan University, AAV-nphs1-shACOX1, AAV-nphs1-null, diabetic kidney disease]
● Molecular Therapy (IF 12.1). Song Z, et.al. (2024). The novel potential therapeutic target PSMP/MSMP promotes acute kidney injury via CCR2. [School of Basic Medical Sciences, Peking University; Peking University First Hospital, AAV9-hPSMP, AAV9-null, acute kidney injury]
● Metabolism Clinical and Experimental (IF 9.8). Zuo Fuwen. (2023). CCDC92 deficiency ameliorates podocyte lipotoxicity in diabetic kidney disease. [School of Basic Medical Sciences, Shandong University, AAV9-Nphs1-Ccdc92, AAV9-Nphs1-shAbca1, intrarenal injection for diabetic kidney disease]
● Cell Death Discovery (IF 7.0). Zhang et.al. (2023). Disruption of RCAN1.4 expression mediated by YY1/HDAC2 modulates chronic renal allograft interstitial fibrosis. [The First Affiliated Hospital of Nanjing Medical University, AAV lentiviral overexpression vectors AAV9-RCAN1.4, LV-RCAN1.4, LV-YY1, kidney]
● Life Sciences (IF 6.780). Hu BC, et.al. (2023). Auto- and paracrine rewiring of NIX-mediated mitophagy by insulin-like growth factor-binding protein 7 in septic AKI escalates inflammation-coupling tubular damage. [Zhejiang Provincial People's Hospital, AAV9-KSP1.3-miR30-sh.NIX & AAV9-sh.scr, septic acute kidney injury]
● Nature Communications (IF 17.694). Yang Y, et.al. (2023). DNA-dependent protein kinase catalytic subunit (DNA-PKcs) drives chronic kidney disease progression in male mice. [Children's Hospital of Nanjing Medical University, AAV8-U6-gRNA-DNA-PKcs; AAV8-U6-gRNA, chronic kidney disease]
● Molecular Therapy (IF 12.910). Ouyang X, et.al. (2022). A protein encoded by circular ZNF609 RNA induces acute kidney injury by activating AKT/mTOR-autophagy pathway. [Guangdong Provincial People's Hospital, AAV9-sh-circ-ZNF609 & AAV9-ZNF609-250 & AAV9-sh-NC, acute kidney injury]
● Cytokine (IF 3.926). Xu H, Wang Z. (2022). MicroRNA-23a-3p ameliorates acute kidney injury by targeting FKBP5 and NF-κB signaling in sepsis. [Jiangxi Provincial People's Hospital, AAV2-miR-23a-3p, septic acute kidney injury]
● Molecular Therapy (IF 12.910). Sung-Ah Hong, et.al. (2021). In vivo gene editing via homology-independent targeted integration for adrenoleukodystrophy treatment. [Yonsei University, AAV9-HITI & AAV9-SaCas9-sgRNA & AAV9-EGFP, adrenoleukodystrophy (ALD)]
● Acta Pharmaceutica Sinica B (IF 11.413). Jing X, et.al. (2021). Gene deficiency or pharmacological inhibition of PDCD4-mediated FGR signaling protects against acute kidney injury. [Shandong University, rAAV9-Fgr-GFP & rAAV9-GFP, acute kidney injury]
● Journal of Pharmacological Sciences (IF 3.337). Zhou J, et.al. (2021). Hyperoside ameliorates diabetic nephropathy induced by STZ via targeting the miR-499-5p/APC axis. [The Affiliated Hospital of Nanjing University of Chinese Medicine, AAV9-miR-499-5p & AAV9-APC, diabetic nephropathy]
● EBioMedicine (IF 5.736). Liu, et.al. (2019). H19 promote calcium oxalate nephrocalcinosis-induced renal tubular epithelial cell injury via a ceRNA pathway. [Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, AAV9-H19, nephrocalcinosis]
● Science Translational Medicine (IF 16.304). Wang, et.al. (2018). Long noncoding RNA lnc-TSI inhibits renal fibrogenesis by negatively regulating the TGF-β/Smad3 pathway. [Southern Medical University, AAV9-MIR-GFP-lnc-TSI, renal fibrosis]

Lung
● Allergy (IF 12.4). Jia M, et.al. (2023). DEL-1, as an anti-neutrophil transepithelial migration molecule, inhibits airway neutrophilic inflammation in asthma. [The First Affiliated Hospital of Nanjing Medical University, AAV6-DEL-1, nasal inhalation, bronchial asthma]
● Microbiology Spectrum (IF 9.043). Zhang Z, et.al. (2023). Long Noncoding RNA AROD Inhibits Host Antiviral Innate Immunity via the miR-324-5p–CUEDC2 Axis. [College of Animal Sciences, Zhejiang University, AAV6-lnc-AROD & AAV6-NC, host innate defense]
● Cell Death & Disease (IF 6.304). Zhang, et.al. (2019). circHIPK3 regulates lung fibroblast-to-myofibroblast transition by functioning as a competing endogenous RNA. [Shanghai General Hospital, AAV6-circHIPK3 shRNA & scrambled shRNA, pulmonary fibrosis]
● Oncotarget. Tian, et.al. (2017). Sirtuin 6 inhibits epithelial to mesenchymal transition during idiopathic pulmonary fibrosis via inactivating TGF-β1/Smad3 signaling. [School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, AAV-Sirt6, idiopathic pulmonary fibrosis]

In Vitro Studies
● Retrovirology (IF 4.183). Wang, et.al. (2017). Genome modification of CXCR4 by Staphylococcus aureus Cas9 renders cells resistance to HIV-1 infection. [School of Basic Medical Sciences, Wuhan University, AAV-SaCas9-CXCR4-gRNA, HIV gene therapy]

Macrophage
● AGING CELL (IF 8). Chen M, et.al. (2025). Senescent Macrophages Promote Age-Related Revascularization Impairment by Increasing Antiangiogenic VEGF-A165B Expression. [Hunan Provincial Maternal and Child Health Care Hospital, AAV9-Lyz2-shVegf-a165b, AAV9-Scramble, age-related revascularization impairment]
● Cell Metabolism (IF 27.287). Loft Anne, et.al. (2022). A macrophage-hepatocyte glucocorticoid receptor axis coordinates fasting ketogenesis. [Helmholtz Center Munich & Ulm University, Germany, AAV-LP1-Cre & AAV-LP1-Cremut, hepatic fasting and ketogenesis]
● EBioMedicine (IF 8.143). Song Haoyu, Xu Tong, Feng Xiaofei, et.al. (2020). Itaconate prevents abdominal aortic aneurysm formation through inhibiting inflammation via activation of Nrf2. [Southern Medical University & Zhuhai Hospital Affiliated with Jinan University, AAV2-Irg1-GFP & AAV2-Nrf2-GFP & AAV2-Keap1-GFP, abdominal aortic aneurysm (AAA)]
● EBioMedicine (IF 5.736). Lian, et.al. (2019). Macrophage metabolic reprogramming aggravates aortic dissection through the HIF1α-ADAM17 pathway. [Peking University, AAV2-ADAM17-GFP & AAV2-GFP, aortic dissection (AD)]
● Circulation Research (IF 14.467). Fu, et.al. (2016). Shift of Macrophage Phenotype Due to Cartilage Oligomeric Matrix Protein Deficiency Drives Atherosclerotic Calcification. [Peking University, AAV2-integrin β3 & AAV2-β-tail domain & AAV2-GFP, atherosclerosis (AS)]

CAR-T Cells
● Leukemia (IF 11.4). Jiang J, et.al. (2023). Inserting EF1α-driven CD7-specific CAR at CD7 locus reduces fratricide and enhances tumor rejection. [School of Medicine, Zhejiang University, AAV-CD7 CAR, CAR-T cell therapy]
● Clinical Cancer Research (IF 13.801). Zhang Y, et.al. (2023). Allogeneic CAR T Cells Targeting DLL3 Are Efficacious and Safe in Preclinical Models of Small Cell Lung Cancer. [Allogene Therapeutics, AAV-IL7 & AAV-IL15, small cell lung cancer]
● Molecular Therapy (IF 12.910). Duan Y, et.al. (2022). Balancing activation and costimulation of CAR tunes signaling dynamics and enhances therapeutic potency. [School of Medicine, Zhejiang University, AAV-TRAC-1928z-WT & AAV-TRAC-1928z-1XX, CAR-T cell preparation]
● Small Methods (IF 15.367). Ruirui Jing, et.al. (2021). Cas9-Cleavage Sequences in Size-Reduced Plasmids Enhance Nonviral Genome Targeting of CARs in Primary Human T Cells. [Zhejiang University, AAV-TRAC-CAR-T]
● Molecular Cell (IF 17.970). Ling, et.al. (2021). Improving the efficiency of CRISPR-Cas12a-based genome editing with site-specific covalent Cas12a-crRNA conjugates. [Peking University, AAV6-CD19 CAR, CAR-T cell preparation]

Gene Editing
● Molecular Therapy: Nucleic Acids (IF 10.183). Iancu O, et.al. (2022). Multiplex HDR for Disease and Correction Modeling of SCID by CRISPR Genome Editing in Human HSPCs. [Bar-Ilan University, AAV6 viral products, severe combined immunodeficiency (SCID)]

Peritoneal Fibrosis
● Journal of Extracellular Vesicles (IF 16). Huang et.al. (2023). Extracellular vesicle-packaged ILK from mesothelial cells promotes fibroblast activation in peritoneal fibrosis. [The Third Affiliated Hospital, Sun Yat-sen University, AAV knockdown vectors, peritoneal fibrosis]

Reproductive system
● Cell Proliferation (IF 5.9). Zhang S, et.al. (2024). AAV-mediated gene therapy restores natural fertility and improves physical function in the Lhcgr-deficient mouse model of Leydig cell failure. [Sun Yat-sen University, AAV8-CAG-Lhcgr, AAVDJ-CAG-Lhcgr, male infertility]
Cell line

Knockout Cell Lines

● BMC Biology (IF 7.364). Ying Z, et al. (2022). CCHCR1–astrin interaction promotes centriole duplication through recruitment of CEP72. [Shenzhen University, HCR-KO HeLa cell line, centriole assembly]

Overexpression Cell Lines
● Cellular & Molecular Immunology (IF 22.096). Lv et al. (2023). Reciprocal costimulatory molecules control the activation of mucosal type 3 innate lymphoid cells during engagement with B cells. [The First Hospital of Jilin University, ICOSL-overexpressing cell line, immunity]

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