Product Literature - WZ Biosciences-Virus Packaging_Adeno-associated virus (AAV)_Adenovirus_Neurotransmitter(NT) Fluorescent Sensors_jGCaMP7_AAV Serotype Screening_Lentivirus_LV_ADV_|AAV_Retrovirus_Optogenetics_Chemical Genetics_CRISPR/Cas9_Autophagy(LC3)_Stable Cell Line Generation

Plasmid

Premade Human ORF Clone：

1.	Cell Death & Disease.(IF=6.304) .Hao et al. (2020) .Dual regulation of p53 by the ribosome maturation factor SBDS.
2.	Cell Death & Disease.(IF=6.304) .Fu et al. (2020) .Activation of STAT3 is a key event in TLR4 signaling-mediated melanoma progression.
3.	Biochemical Pharmacology.(IF=4.96) .Li et al. (2020) .Downregulation of OCTN2 by Cytokines Plays an Important Role in the Progression of Inflammatory Bowel Disease.
4.	Cancer Letters.(IF=7.36) .Liu et al. (2020) .MICAL2 is a novel nucleocytoplasmic shuttling protein promoting cancer invasion and growth of lung adenocarcinoma.
5.	Cancer Letters.(IF=7.36) .Luo et al. (2019) .DMBX1 promotes tumor proliferation and regulates cell cycle progression via repressing OTX2-mediated transcription of p21 in lung adenocarcinoma cell.
6.	Redox Biology.(IF=9.986) .Tian et al. (2019) .aPKCι promotes gallbladder cancer tumorigenesis and gemcitabine resistance by competing with Nrf2 for binding to Keap1.

Premade Human microRNA Clone：

1.	Pharmacological Research.(IF=5.893) .Huang et al. (2020) .MiR-377-3p suppresses colorectal cancer through negative regulation on Wnt/β-catenin signaling by targeting XIAP and ZEB2.
2.	PPAR Research.(IF=2.953) .Xu et al. (2019) .Peroxisome Proliferator-Activated Receptor-γ Antagonizes LOX-1-Mediated Endothelial Injury by Transcriptional Activation of miR-590-5p.
3.	Theranostics.(IF=8.579) .Song et al. (2019) .Localized injection of miRNA-21-enriched extracellular vesicles effectively restores cardiac function after myocardial infarction.

Custom Clone：

1.	Cell Death Dis. (IF=6.304). Ma, et al. (2020). circ5615 functions as a ceRNA to promote colorectal cancer progression by upregulating TNKS.
2.	Toxicol. Appl. Pharmacol. (IF=3.347). Ge & Tu, et al. (2020). MiR-122-5p increases radiosensitivity and aggravates radiation-induced rectal injury through CCAR1.
3.	Cell Death Dis. (IF=6.304). Zhang, et al. (2019). circHIPK3 regulates lung fibroblast-to-myofibroblast transition by functioning as a competing endogenous RNA.
4.	Int J Med Sci. (IF=2.523). Wang, et al. (2019). LncRNA SNHG6 promotes proliferation, invasion and migration in colorectal cancer cells by activating TGF-β/Smad signaling pathway via targeting UPF1 and inducing EMT via regulation of ZEB1.
5.	EBioMedicine. (IF=5.736). Jiang, et al. (2019). Overexpression of PIMREG promotes breast cancer aggressiveness via constitutive activation of NF-κB signaling.
6.	Aging (Albany NY). (IF=4.831). Li, et al. (2019). Sirt1-inducible deacetylation of p21 promotes cardiomyocyte proliferation.
7.	R Soc Open Sci. (IF=2.647). Liu, et al. (2018). Loss of miR-143 and miR-145 in condyloma acuminatum promotes cellular proliferation and inhibits apoptosis by targeting NRAS.

Adenovirus

Premade Human ORF Adenovirus：

1.	Biol Psychiatry. (IF=12.095). Zhao D, et al. (2019). RPS23RG1 Is Required for Synaptic Integrity and Rescues Alzheimer's Disease-Associated Cognitive Deficits.
2.	J Clin Endocrinol Metab. (IF=5.399). Li M, et al. (2019). The HMGA2-IMP2 Pathway Promotes Granulosa Cell Proliferation in Polycystic Ovary Syndrome.
3.	Int J Cardiol. (IF=3.229). Wu B, et al. (2018). Mesoderm/mesenchyme homeobox gene l promotes vascular smooth muscle cell phenotypic modulation and vascular remodeling.
4.	Life Sci. (IF=6.304). He M, et al. (2018). In vitro study of FUZ as a novel potential therapeutic target in non-small-cell lung cancer.
5.	Cell Death Dis. (IF=6.304). Sun S, et al. (2017). Loss of the novel mitochondrial protein FAM210B promotes metastasis via PDK4-dependent metabolic reprogramming.
6.	Molecular Medicine Reports. (IF=2.1). Zhang S, et al. (2017). PAR1-mediated c-Jun activation promotes heat stress-induced early stage apoptosis of human umbilical vein endothelial cells.
7.	Hepatology. (IF=14.679). Xiang D, et al. (2017). Shp2 promotes liver cancer stem cell expansion by augmenting β-atenin signaling and predicts chemotherapeutic response of patients.
8.	Cancer Letters. (IF=7.36). Wang Z , et al . (2017). CXCL1 from tumor-associated lymphatic endothelial cells drives gastric cancer cell into lymphatic system via activating integrinβ1/FAK/AKT signaling.
9.	Gene. (IF=2.984). Zhang J W, et al. (2017). Validation of aspirin response-related transcripts in patients with coronary artery disease and preliminary investigation on CMTM5 function.
10.	Cell Death Dis. (IF=6.304). Zheng Y, et al. (2017). Berbamine postconditioning protects the heart from ischemia/reperfusion injury through modulation of autophagy.
11.	Oncoimmunology. (IF=5.869). Wang H, et al. (2016). Interactions between colon cancer cells and tumor-infiltrated macrophages depending on cancer cell-derived colony stimulating factor 1.
12.	Basic Res Cardiol. (IF=11.981). Sun Z, et al. (2016). Cross-talk between macrophages and atrial myocytes in atrial fibrillation.
13.	Mol Carcinog. (IF=3.825). Wang J, et al. (2016). Endothelial cell-anchored tissue factor pathway inhibitor regulates tumor metastasis to the lung in mice.

Premade Human microRNA Adenovirus：

1.	Stem Cells Int. (IF=3.869). Li X, et al. (2019). MicroRNA-150 Modulates Adipogenic Differentiation of Adipose-Derived Stem Cells by Targeting Notch3.
2.	Oncotarget. (IF=5.168). Tian S, et al. (2017). miR-138-5p suppresses autophagy in pancreatic cancer by targeting SIRT1.

Gene Overexpression：

1.	Elife Tool. (IF=7.08). Wu L, et al. (2019). PARIS, an optogenetic method for functionally mapping gap junctions.
2.	Cell Death Dis. (IF=6.304). Su Y, et al. (2019). MicroRNA-181a-5p and microRNA-181a-3p cooperatively restrict vascular inflammation and atherosclerosis.
3.	EBioMedicine. (IF=5.736). Wang K, et al. (2019). TGF-beta1/p65/MAT2A pathway regulates liver fibrogenesis via intracellular SAM.
4.	Arthritis Res Ther. (IF=4.103). Zeng J, et al. (2019). Interferon-alpha exacerbates neuropsychiatric phenotypes in lupus-prone mice.
5.	Oncogene. (IF=7.971). Yu M, et al. (2018). Circadian regulator NR1D2 regulates glioblastoma cell proliferation and motility.
6.	Cell Death Discov. (IF=4.114). Zhang SQ, et al. (2018). Oleanolic acid enhances neural stem cell migration, proliferation, and differentiation in vitro by inhibiting GSK3beta activity.
7.	Int J Mol Med. (IF=3.098). Zhang L, et al. (2018). Anti-inflammatory effects of Lefty-1 in renal tubulointerstitial inflammation via regulation of the NF-kappaB pathway.
8.	Redox Biol. (IF=9.986). Jin Q, et al. (2018). DUSP1 alleviates cardiac ischemia/reperfusion injury by suppressing the Mff-required mitochondrial fission and Bnip3-related mitophagy via the JNK pathways.
9.	Cell Physiol Biochem. (IF=5.5). Wang Y, et al. (2018). Inhibition of Histone Deacetylases Prevents Cardiac Remodeling After Myocardial Infarction by Restoring Autophagosome Processing in Cardiac Fibroblasts.
10.	Brain,Behavior,and Immunity. (IF=6.633). Zhou Y.T, et al. (2017). Interleukin-1βimpedes oligodendrocyte progenitor cell recruitment and white matter repair following chronic cerebral hypoperfusion.
11.	J Pharmacol Sci. (IF=2.835). Li J, et al. (2016). PKCζ interacts with STAT3 and promotes its activation in cardiomyocyte hypertrophy.
12.	Arthritis Rheumatol. (IF=9.586). Han X, et al. (2016). MicroRNA-130b Ameliorates Murine Lupus Nephritis Through Targeting the Type I Interferon Pathway on Renal Mesangial Cells.
13.	Sci Rep. (IF=3.998). Zhang H, et al. (2016). Endogenous sulfur dioxide is a novel adipocyte-derived inflammatory inhibitor. entific Reports.
14.	Mol Cell Biol. (IF=3.611). Wu C, et al. (2016). Phosphatidylinositol 3-Kinase/Akt Mediates Integrin Signaling To Control RNA Polymerase I Transcriptional Activity.

Gene Silencing：

1.	Journal of Cellular and Molecular Medicine. (IF=4.486). Wang, et al. (2020). Inhibition of PFKFB3 suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss.
2.	EBioMedicine. (IF=5.736. Li, et al. (2019). Inhibition of AZIN2-sv induces neovascularization and improves prognosis after myocardial infarction by blocking ubiquitin-dependent talin1 degradation and activating the Akt pathway.
3.	Bone. (IF=4.147). Zhao, et al. (2018). YAP1 is essential for osteoclastogenesis through a TEADs-dependent mechanism.
4.	Cardiovascular Research. (IF=8.168. Li, et al. (2018). Loss of AZIN2 splice variant facilitates endogenous cardiac regeneration.
5.	Br J Pharmacol. (IF=6.304). Ma Z.G, et al. (2016). Protection against cardiac hypertrophy by geniposide involves the GLP-1 receptor / AMPKalpha signalling pathway.
6.	Clin Sci . (IF=5.223). Ling Y, et al. (2016). Polydatin post-treatment alleviates myocardial ischaemia/reperfusion injury by promoting autophagic flux.
7.	Int J Biol Sci. (IF=4.858). Ma Z G, et al. (2016). Asiatic Acid Protects against Cardiac Hypertrophy through Activating AMPKalpha Signalling Pathway.

Gene Editing：

1.

Int. J. Mol. Sci. (IF=4.556). Xu, et al. (2020). Effective MSTN Gene Knockout by AdV-Delivered CRISPR/Cas9 in Postnatal Chick Leg Muscle.

Lentivirus

Overexpression：

1.	Cell Death & Disease. (IF=6.304). Liu, et al. (2020). Long noncoding RNA SNHG12 promotes tumour progression and sunitinib resistance by upregulating CDCA3 in renal cell carcinoma.
2.	Cell Death & Disease. (IF=6.304). Liu, et al. (2020). Activation of STAT3 is a key event in TLR4 signaling-mediated melanoma progression.
3.	Cell Death & Disease. (IF=6.304). Wang, et al. (2019). LXRα promotes cell metastasis by regulating the NLRP3 inflammasome in renal cell carcinoma.
4.	Biochemical and Biophysical Research Communications. (IF=2.985). Zhu, et al. (2019). MicroRNA-506 inhibits the proliferation and invasion of mantle cell lymphoma cells by targeting B7H3.
5.	Molecular Cancer. (IF=15.302). Tan, et al. (2019). PIWI-interacting RNA-36712 restrains breast cancer progression and chemoresistance by interaction with SEPW1 pseudogene SEPW1P RNA.
6.	Advanced Science. (IF=15.84). Lai, et al. (2018). A Modular Assembly of Spinal Cord–Like Tissue Allows T argeted Tissue Repair in the T ransected Spinal Cord.
7.	Theranostics. (IF=8.579). Mai, et al. (2018). PIWI-interacting RNA-54265 is oncogenic and a potential therapeutic target in colorectal adenocarcinoma.
8.	Toxicology Letters. (IF= 3.569). Yan, et al. (2018). Inhibitory Effect of PXR on Ammonia-induced Hepatocyte Autophagy via P53.

Gene Silencing：

1.	Cell Death & Disease. (IF=6.304). You, et al. (2020). GADD45α drives brown adipose tissue formation through upregulating PPARγ in mice.
2.	Journal of Neuroinflammation. (IF=5.793). Zeng, et al. (2019). Lentivirus-mediated downregulation of α-synuclein reduces neuroinflammation and promotes functional recovery in rats with spinal cord injury.
3.	Cell Discovery. (IF=6.255). Liao, et al. (2019). USP10 modulates the SKP2/Bcr-Abl axis via stabilizing SKP2 in chronic myeloid leukemia.
4.	International Journal of Biological Sciences. (IF=4.858). Zheng, et al. (2019). Cathelicidin-related antimicrobial peptide protects against cardiac fibrosis in diabetic mice heart by regulating endothelial-mesenchymal transition.
5.	Oncogene. (IF=7.971). Liao, et al. (2018). Growth arrest and apoptosis induction in androgen receptor-positive human breast cancer cells by inhibition of USP14-mediated androgen receptor deubiquitination.
6.	J Mol Cell Cardiol. (IF= 4.133). Li, et al. (2017). TCONS_00075467 modulates atrial electrical remodeling by sponging miR-328 to regulate CACNA1C.

Adeno-associated Virus (AAV) -Nervous System

1.	Nature Communications. (IF=12.121). Xu, et.al. (2020). CircGRIA1 shows an age-related increase in male macaque brain and regulates synaptic plasticity and synaptogenesis.
2.	Science Advances. (IF=13.116). Sun, et.al. (2020). Development of a CRISPR-SaCas9 system for projection- and function-specific gene editing in the rat brain.
3.	The Journal of Neuroscience. (IF=5.673). Zingg B, et.al. (2020). Synaptic Specificity and Application of Anterograde Transsynaptic AAV for Probing Neural Circuitry.
4.	Molecular Psychiatry. (IF=12.384). li, et.al. (2020). Programmed cell death 4 as an endogenous suppressor of BDNF translation is involved in stress-induced depression.
5.	Biological Psychiatry. (IF=12.095). Zhang, et.al. (2020). Reduced neuronal cAMP in the nucleus accumbens damages blood-brain barrier integrity and promotes stress vulnerability.
6.	Cell Reports. (IF=8.109). Ma, et.al. (2019). Spontaneous Pain Disrupts Ventral Hippocampal CA1-Infralimbic Cortex Connectivity and Modulates Pain Progression in Rats with Peripheral Inflammation.
7.	Cell. (IF=38.637). Fan, et.al. (2019). Stress-Induced Metabolic Disorder in Peripheral CD4+T Cells Leads to Anxiety-like Behavior.
8.	Neuron. (IF=14.415). Feng, et.al. (2019). A Genetically Encoded Fluorescent Sensor for Rapid and Speciﬁc In Vivo Detection of Norepinephrine.
9.	Cell. (IF=38.637). Sun, et.al. (2018). A Genetically Encoded Fluorescent Sensor Enables Rapid and Speciﬁc Detection of Dopamine in Flies,Fish, and Mice.
10.	Behavioural Neurology. (IF=2.093). Qu, et.al. (2018). MST1 Suppression Reduces Early Brain Injury by Inhibiting the NF-κB/MMP-9 Pathway after Subarachnoid Hemorrhage in Mice.
11.	Neuron. (IF=14.415). Zingg B, et.al. (2017). AAV-Mediated Anterograde Transsynaptic Tagging: Mapping Corticocollicular Input-Defined Neural Pathways for Defense Behaviors.

Adeno-associated Virus (AAV) -Circulatory System

Heart：

1.	Hypertension. (IF=7.713). Liu, Wen, Li, et.al. (2020). Oleic Acid Attenuates Ang II（Angiotensin II）-Induced Cardiac Remodeling by Inhibiting FGF23（Fibroblast Growth Factor 23.
2.	International Journal of Molecular Medicine. (IF=3.098). Huang, et.al. (2019). Redd1 protects against post-infarction cardiac dysfunction by targeting apoptosis and autophagy.
3.	Frontiers in Pharmacology. (IF=4.225). Shen, et.al. (2019). Downregulation of miR-146a Contributes to Cardiac Dysfunction Induced by the Tyrosine Kinase Inhibitor Sunitinib.
4.	Journal of Molecular and Cellular Cardiology. (IF=4.133). Wu, et.al. (2019). The protective effect of high mobility group protein HMGA2 in pressure overload-induced cardiac remodeling.
5.	Biochemical and Biophysical Research Communications. (IF=2.985). Yang, et.al. (2018). Vaspin alleviates myocardial ischaemia/reperfusion injury via activating autophagic ﬂux and restoring lysosomal function.

Blood Vessel：

1.	Arteriosclerosis, Thrombosis, and Vascular Biology. (IF=6.604). Zhao, et.al. (2019). ALDH2 (Aldehyde Dehydrogenase 2) Protects Against Hypoxia-Induced Pulmonary Hypertension.
2.	Journal of Molecular and Cellular Cardiology. (IF=4.133). Sun, et.al. (2019). LncRNA H19 promotes vascular inflammation and abdominal aortic aneurysm formation by functioning as a competing endogenous RNA.
3.	Journal of Cerebral Blood Flow & Metabolism. (IF=5.681). Li, et.al. (2019). Overexpression of LH3 reduces the incidence of hypertensive intracerebral hemorrhage in mice.
4.	Arteriosclerosis, Thrombosis, and Vascular Biology. (IF=6.604). Zhong, et.al. (2019). SM22α (Smooth Muscle 22α) Prevents Aortic Aneurysm Formation by Inhibiting Smooth Muscle Cell Phenotypic Switching Through Suppressing Reactive Oxygen Species/NF-κB (Nuclear Factor-κB).

Adeno-associated Virus (AAV) -Digestive System

Adeno-associated Virus (AAV) -Other Systems

Skin：

1.

International Journal of Biological Sciences. (IF=4.858). Wu, et.al. (2019). Metformin Promotes the Survival of Random-Pattern Skin Flaps by Inducing Autophagy via the AMPK-mTOR-TFEB signaling pathway.

Kidney：

1.	EBIOMEDICINE. (IF=5.736). Liu, et.al. (2019). H19 promote calcium oxalate nephrocalcinosis-induced renal tubular epithelial cell injury via a ceRNA pathway.
2.	Science Translational Medicine. (IF=16.304). Wang, et.al. (2018). Long noncoding RNA lnc-TSI inhibits renal fibrogenesis by negatively regulating the TGF-β/Smad3 pathway.

Lung：

1.	Cell Death & Disease. (IF=6.304). Zhang, et.al. (2019). circHIPK3 regulates lung fibroblast-to-myofibroblast transition by functioning as a competing endogenous RNA.
2.	Oncotarget. Tian, et.al. (2017). Sirtuin 6 inhibits epithelial to mesenchymal transition during idiopathic pulmonary fibrosis via inactivating TGF-β1/Smad3 signaling.

In Vitro Studies：

1.

Retrovirology. (IF=4.183). Wang, et.al. (2017). Genome modifcation of CXCR4 by Staphylococcus aureus Cas9 renders cells resistance to HIV-1 infection.

Macrophages：

1.	EBioMedicine. (IF=5.736). Lian, et.al. (2019). Macrophage metabolic reprogramming aggravates aortic dissection through the HIF1α-ADAM17 pathway.
2.	Circulation Research. (IF=14.467). Fu, et.al. (2016). Shift of Macrophage Phenotype Due to Cartilage Oligomeric Matrix Protein Defciency Drives Atherosclerotic Calcifcation.

1.	Proc. Natl. Acad. Sci. U.S.A. (PNAS). (IF=9.412). Zhang, et.al. (2020). Hepatic neddylation targets and stabilizes electron transfer flavoproteins to facilitate fatty acid β-oxidation.
2.	Journal of Hepatology. (IF=20.582). She, et.al. (2019). PSMP/MSMP promotes hepatic ﬁbrosis through CCR2 and represents a novel therapeutic target.
3.	Theranostics. (IF=8.579). Liu, et.al. (2019). Suppression of YAP/TAZ-Notch1-NICD axis by bromodomain and extraterminal protein inhibition impairs liver regeneration.
4.	Molecular Cell. (IF=15.584). Wan, et.al. (2019). Pacer is a mediator of mTORC1 and GSK3-TIP60 signaling in regulation of autophagosome maturation and lipid metabolism.
5.	Experimental Cell Research. (IF=3.383). Li, et.al. (2018). Brg1 promotes liver fibrosis via activation of hepatic stellate cells.
6.	Molecular Cell. (IF=15.584). Wan, et.al. (2018). mTORC1-Regulated and HUWE1-Mediated WIPI2 Degradation Controls Autophagy Flux.
7.	Molecular Cell. (IF=15.584). Su, et.al. (2017). VPS34 Acetylation Controls Its Lipid Kinase Activity and the Initiation of Canonical and Non-canonical Autophagy.
8.	Proc. Natl. Acad. Sci. U.S.A. (PNAS). (IF=9.412). He, et.al. (2017). MicroRNA-351 promotes schistosomiasis-induced hepatic fibrosis by targeting the vitamin D receptor.

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