Tissue-Specific AAV Serotypes (Partial List)
|
Serotype |
Infected Tissue |
|
AAV1 |
Nervous system (high-titer anterograde trans-synaptic), muscle, skeletal muscle, cardiac muscle, smooth muscle |
|
AAV2 |
retina, nervous system, muscles, liver, vascular smooth muscle |
|
AAV2-retro |
Nervous system (retrograde non-trans-synaptic) |
|
AAV4 |
Central Nervous System, Retina, Lung, Kidney |
|
AAV5 |
Nervous system, lung, retina, liver, synovial joint, epithelial cell |
|
AAV6 |
Nervous system, lungs, muscles, heart |
|
AAV6.2 |
Nervous system, lungs, muscles, heart |
|
AAV7 |
muscle, liver |
|
AAV8 |
Nervous system, liver, muscle, adipose tissue, pancreas, retina |
|
AAV9 |
Nervous system, lungs, muscles, heart |
|
AAV9.2 |
Nervous system, lungs, muscles, heart |
|
AAV11 |
Astrocyte |
|
AAV-B10 |
Targeting neurons, crossing the blood-brain barrier |
|
AAV-PHP.B |
cross the blood-brain barrier |
|
AAV-PHP.EB |
cross the blood-brain barrier |
|
AAV-PHP.S |
cross the blood-brain barrier |
|
AAV-cMG |
Microglia (in vitro) |
|
AAV-MG1.1 |
Microglia (in vivo) |
|
AAV-MG1.2 |
Microglia (in vivo) |
|
AAV.CPP16 |
central nervous system neurons |
|
AAV.CC47 |
central nervous system neurons |
|
AAV-BI30 |
central vascular endothelial cells |
|
AAV-BR1 |
cerebrovascular endothelium |
|
AAV9-RGDLRVS |
Peripheral endothelial cells |
|
AAV-EC |
vascular endothelium |
|
AAV-rh10 |
Liver, blood, heart, cells infected in vitro |
|
AAV-DJ |
retina, lung, kidney, extracorporeal infected cells |
|
AAV-REC2 |
fat |
|
AAV-shh10 |
retina |
|
AAV-7M8 |
retina |
|
AAV-Anc80 |
Inner ear, retina, skeletal muscle, liver |
|
AAVie |
Inner ear |
|
AAV-Pan |
pancreas |
|
AAV-Kera2 |
skin |
|
AAV-MYO |
muscle |
Tissue-Specific Promoter (Partial List)
|
Organization |
Promoter Name |
Promoter Description |
|
Neuron |
hSyn |
neuronal promoter |
|
NSE |
neuronal promoter |
|
|
mecp2 |
short neuronal promoter |
|
|
c-fos |
Promoter for activated neurons |
|
|
CaMKIIa |
Excitatory neuron promoter in forebrain glutamatergic neurons, neocortex and hippocampus |
|
|
S5E2 |
PV-positive cortical interneuron promoter |
|
|
PV |
Inhibitory interneuron promoter |
|
|
ChAT |
Cholinergic neuron promoter |
|
|
SST |
GABAergic inhibitory neuron promoter |
|
|
TH |
Dopaminergic neuron promoter |
|
|
PET |
Serotonergic neuron promoter |
|
|
mDlx |
GABAergic interneuron promoter |
|
|
oxytocin |
Oxytocinergic neuron promoter |
|
|
Vglut2 |
Glutamatergic neuron promoter |
|
|
Vglut1 |
Glutamatergic neuron promoter |
|
|
PRSx8 |
Noradrenergic neuron promoter |
|
|
GAD2-mGAD65(GAD65) |
GABAergic inhibitory neuron promoter |
|
|
CD68 |
Microglia/monocyte-macrophage promoter |
|
|
CX3CR1 |
Microglia/monocyte-macrophage promoter |
|
|
F4/80 |
Microglia/macrophage promoter |
|
|
gfaABC1D |
Astrocyte promoter |
|
|
GFAP |
Astrocyte promoter |
|
|
GFAP104 |
Astrocyte promoter |
|
|
ALDH1L1 |
Astrocyte promoter in thalamus |
|
|
MBP |
Oligodendrocyte promoter |
|
|
NG2 |
Oligodendrocyte precursor cell promoter |
|
|
Nestin |
Neural stem cell promoter |
|
|
Eye |
Rpe65 |
Retinal pigment epithelial cell promoter |
|
VMD2 |
Retinal pigment epithelial cell promoter |
|
|
mSncg |
Retinal ganglion cell (RGC) promoter |
|
|
PR1.7 |
Cone photoreceptor promoter |
|
|
Rhodopsin(RHO) |
Rod photoreceptor promoter |
|
|
GRK1 |
Rod and cone photoreceptor promoter |
|
|
Bone marrow cell |
CD11B |
Mature myeloid cell promoter (neutrophils, monocytes and macrophages) |
|
Lyz2 |
Myeloid cell promoter (monocytes, mature macrophages, granulocytes) |
|
|
Suspension cell |
SFFV |
Promoter for hematological tumor cells, immune cells and hematopoietic stem cells |
|
Blood vessel |
SM22a |
Vascular smooth muscle promoter |
|
EnSM22a |
Vascular smooth muscle promoter |
|
|
SM22a-L |
Vascular smooth muscle promoter |
|
|
ICAM2 |
Vascular endothelial promoter |
|
|
CDH5 |
Vascular endothelial promoter |
|
|
TIE1 |
Vascular endothelial promoter |
|
|
Heart |
cTNT |
Cardiomyocyte promoter |
|
aMHC |
Cardiac cell promoter |
|
|
ANF |
Atrial cell promoter |
|
|
Msln |
Epicardial cell promoter |
|
|
Fibroblast |
COL1A2 |
Cardiac fibroblast promoter |
|
TCF21 |
Cardiac fibroblast promoter |
|
|
FSP1 |
Cardiac fibroblast promoter |
|
|
Periostin(POSTN) |
Cardiac fibroblast promoter |
|
|
Liver |
TBG |
Hepatocyte promoter |
|
ALB |
Hepatocyte promoter |
|
|
HCRApoE/hAAT |
Hepatocyte promoter |
|
|
CK19 |
Biliary epithelial cell and cholangiocarcinoma cell promoter |
|
|
mLRAT |
Hepatic stellate cell promoter (mouse) |
|
|
hLRAT |
Hepatic stellate cell promoter (human) |
|
|
Pancreas |
Insulin(RIP2) |
Pancreatic β-cell promoter |
|
elastase |
Pancreatic exocrine gland cell promoter |
|
|
Gcg |
Pancreatic alpha cell promoter |
|
|
Kidney |
Ksp1.3 |
Renal tubular epithelial cell promoter |
|
NPHS1 |
Renal podocyte promoter |
|
|
Intestine |
Villin |
Intestinal epithelial cell promoter |
|
Bone |
Osterix |
Osteoblast promoter |
|
COL2A1 |
Chondrocyte promoter |
|
|
Muscle |
MCK |
Skeletal muscle promoter |
|
3xMCK |
Skeletal muscle promoter |
|
|
CK6 |
Skeletal muscle promoter |
|
|
MHCK7 |
Skeletal muscle-specific promoter |
|
|
Adipose |
Adipoq-2266 |
Adipocyte promoter |
|
Adipoq-875 |
Adipocyte promoter |
|
|
UCP1 |
Brown adipocyte promoter |
|
|
Skin |
K14 |
Epidermal keratinocyte promoter |
|
K18 |
Epidermal cell promoter |
|
|
Esophagus |
hNKX6.1 |
Esophageal cell promoter |