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Weizhen Biosciences Tissue-Specific AAV Serotypes & Promoter



Tissue-Specific AAV Serotypes (Partial List)


Serotype

Infected Tissue

AAV1

Nervous system (high-titer anterograde trans-synaptic), muscle, skeletal muscle, cardiac muscle, smooth muscle

AAV2

retina, nervous system, muscles, liver, vascular smooth muscle

AAV2-retro

Nervous system (retrograde non-trans-synaptic)

AAV4

Central Nervous System, Retina, Lung, Kidney

AAV5

Nervous system, lung, retina, liver, synovial joint, epithelial cell

AAV6

Nervous system, lungs, muscles, heart

AAV6.2

Nervous system, lungs, muscles, heart

AAV7

muscle, liver

AAV8

Nervous system, liver, muscle, adipose tissue, pancreas, retina

AAV9

Nervous system, lungs, muscles, heart

AAV9.2

Nervous system, lungs, muscles, heart

AAV11

Astrocyte

AAV-B10

Targeting neurons, crossing the blood-brain barrier

AAV-PHP.B

cross the blood-brain barrier

AAV-PHP.EB

cross the blood-brain barrier

AAV-PHP.S

cross the blood-brain barrier

AAV-cMG

Microglia (in vitro)

AAV-MG1.1

Microglia (in vivo)

AAV-MG1.2

Microglia (in vivo)

AAV.CPP16

central nervous system neurons

AAV.CC47

central nervous system neurons

AAV-BI30

central vascular endothelial cells

AAV-BR1

cerebrovascular endothelium

AAV9-RGDLRVS

Peripheral endothelial cells

AAV-EC

vascular endothelium

AAV-rh10

Liver, blood, heart, cells infected in vitro

AAV-DJ

retina, lung, kidney, extracorporeal infected cells

AAV-REC2

fat

AAV-shh10

retina

AAV-7M8

retina

AAV-Anc80

Inner ear, retina, skeletal muscle, liver

AAVie

Inner ear

AAV-Pan

pancreas

AAV-Kera2

skin

AAV-MYO

muscle




Tissue-Specific Promoter (Partial List)


Organization

Promoter Name

Promoter Description

Neuron

hSyn

neuronal promoter

NSE

neuronal promoter

mecp2

short neuronal promoter

c-fos

Promoter for activated neurons

CaMKIIa

Excitatory neuron promoter in forebrain glutamatergic neurons, neocortex and hippocampus

S5E2

PV-positive cortical interneuron promoter

PV

Inhibitory interneuron promoter

ChAT

Cholinergic neuron promoter

SST

GABAergic inhibitory neuron promoter

TH

Dopaminergic neuron promoter

PET

Serotonergic neuron promoter

mDlx

GABAergic interneuron promoter

oxytocin

Oxytocinergic neuron promoter

Vglut2

Glutamatergic neuron promoter

Vglut1

Glutamatergic neuron promoter

PRSx8

Noradrenergic neuron promoter

GAD2-mGAD65(GAD65)

GABAergic inhibitory neuron promoter

CD68

Microglia/monocyte-macrophage promoter

CX3CR1

Microglia/monocyte-macrophage promoter

F4/80

Microglia/macrophage promoter

gfaABC1D

Astrocyte promoter

GFAP

Astrocyte promoter

GFAP104

Astrocyte promoter

ALDH1L1

Astrocyte promoter in thalamus

MBP

Oligodendrocyte promoter

NG2

Oligodendrocyte precursor cell promoter

Nestin

Neural stem cell promoter

Eye

Rpe65

Retinal pigment epithelial cell promoter

VMD2

Retinal pigment epithelial cell promoter

mSncg

Retinal ganglion cell (RGC) promoter

PR1.7

Cone photoreceptor promoter

Rhodopsin(RHO)

Rod photoreceptor promoter

GRK1

Rod and cone photoreceptor promoter

Bone marrow cell

CD11B

Mature myeloid cell promoter (neutrophils, monocytes and macrophages)

Lyz2

Myeloid cell promoter (monocytes, mature macrophages, granulocytes)

Suspension cell

SFFV

Promoter for hematological tumor cells, immune cells and hematopoietic stem cells

Blood vessel

SM22a

Vascular smooth muscle promoter

EnSM22a

Vascular smooth muscle promoter

SM22a-L

Vascular smooth muscle promoter

ICAM2

Vascular endothelial promoter

CDH5

Vascular endothelial promoter

TIE1

Vascular endothelial promoter

Heart

cTNT

Cardiomyocyte promoter

aMHC

Cardiac cell promoter

ANF

Atrial cell promoter

Msln

Epicardial cell promoter

Fibroblast

COL1A2

Cardiac fibroblast promoter

TCF21

Cardiac fibroblast promoter

FSP1

Cardiac fibroblast promoter

Periostin(POSTN)

Cardiac fibroblast promoter

Liver

TBG

Hepatocyte promoter

ALB

Hepatocyte promoter

HCRApoE/hAAT

Hepatocyte promoter

CK19

Biliary epithelial cell and cholangiocarcinoma cell promoter

mLRAT

Hepatic stellate cell promoter (mouse)

hLRAT

Hepatic stellate cell promoter (human)

Pancreas

Insulin(RIP2)

Pancreatic β-cell promoter

elastase

Pancreatic exocrine gland cell promoter

Gcg

Pancreatic alpha cell promoter

Kidney

Ksp1.3

Renal tubular epithelial cell promoter

NPHS1

Renal podocyte promoter

Intestine

Villin

Intestinal epithelial cell promoter

Bone

Osterix

Osteoblast promoter

COL2A1

Chondrocyte promoter

Muscle

MCK

Skeletal muscle promoter

3xMCK

Skeletal muscle promoter

CK6

Skeletal muscle promoter

MHCK7

Skeletal muscle-specific promoter

Adipose

Adipoq-2266

Adipocyte promoter

Adipoq-875

Adipocyte promoter

UCP1

Brown adipocyte promoter

Skin

K14

Epidermal keratinocyte promoter

K18

Epidermal cell promoter

Esophagus

hNKX6.1

Esophageal cell promoter